After the events at the hospital, the brothers have no idea where the demon that killed their mother is hiding. While biding their time trying to come up with an idea, they investigate murders committed by a killer clown.
Sam and Dean meet Andy Gallagher, a slacker with psychic powers of persuasion. Once the brothers learn that Andy’s family was visited by the Demon, Sam wonders if he could be one of the special children.
Sam and Dean investigate the slayings of blonde women and find that the ghost of the first known serial killer in US history is responsible. Jo disobeys Ellen's wishes and follows them along, and is captured by the ghost.
Sam and Dean allow themselves to be arrested in order to investigate a series of murders inside a penitentiary. However things get complicated when FBI agent Henricksen shows up to take over their case.