Megan Donner returns to the CSI unit in time to work on a jet crash in the Everglades. While searching for survivors, they inexplicably discover a female victim found five miles from the crash site. When the only survivor says the woman opened the plane's hatch in order to commit suicide, Horatio is suspicious. The team must now recreate what happened on that fatal flight, especially when the pieces don't quite fit together.

A serial bomber is on the loose. Will the team with the help from Caine's old bomb squad mentor be able to work out the puzzle and find the bomber?

Horatio, Calleigh and Speedle investigate the death of an exotic male dancer found dead after a sexual party, and must dig through the evidence to discover a motive. Meanwhile, Eric and Megan investigate the death of a man involved in diving that mysteriously died after climbing onto a random boat.

The team investigates the death of a young model, whose body was found near a juvenile detention camp for girls. Across town, Delko and Speedle probe the bizarre death of a man who was apparently burned from the inside.

Shortly before Horatio is set to testify at a high-profile murder case in which the defendant is the husband of a city councilwoman, he's given new facts that could prove the man is innocent. The information revolves around the discovery of a second victim who matches the profile of the first one and was killed in a similar manner. If the man on trial isn't guilty, then Horatio fears that a serial killer may be on the loose.

The team investigates the deaths of two college students who were in Miami on spring break. The first is a teenage girl found dead on a beach with her neck broken and human bite marks on her legs. The second is a young man found in the bottom of a hotel swimming pool who apparently died before he hit the water.

An inmate at a massive Miami prison complex is stabbed to death in the prison yard. Shortly after Horatio arrives on the scene, a helicopter appears above the correctional facility. He immediately fears that the murder was a decoy to set up an escape. That's confirmed as three prisoners hop aboard the chopper and flee. As the investigation gets underway, the identities of the fugitives become known and a horrible realization sweeps over Horatio: two of the escapees are cold-blooded killers who already have their next victims picked out, and the other is a child molester who he recently put away.

When a teen tennis phenom is abducted from her bedroom, the investigation leads to the waterways when a girl's arm is recovered in the belly of a alligator. Delko calls for an expert - his old college buddy and now alligator expert Jeff Corwin to assist.

A gas man is engulfed in invisible flames and dies during a qualifying race at the Grand Prix Americas.

A young woman is attacked by a shark and later dies, but it's discovered that she was shot first. The case becomes even more difficult for the CSIs when one of their coworkers becomes a leading suspect. The dead woman worked for a private-investigation agency that specializes in luring and entrapping married men suspected of infidelity.

A celebrity photographer is found dead in his car following an accident, but Horatio believes he was murdered. The investigation leads to an A-list movie star who was caught in a compromising position in photos taken by the paparazzi.

Horatio and Speedle's case hinges on the testimony of a forensic-evidence enthusiast who stole a blood-drenched latex glove from the scene of the murder of a man who was stabbed to death with a butterfly knife. When Speedle tracks him down, the CSI wannabe is impressed by the ease with which Speedle was able to locate him, and the two begin to develop a slight bond when he shows up at the crime lab the night before he is set to testify. However, their relationship is cut short when the young man is found dead in his forensics-shrine of a home. Meanwhile, Delko and Calleigh probe the shooting death of a young woman whose body is found wrapped in a plastic garbage bag in a dumpster near the ritzy Miami club where she worked.

An adult film actress is found strangled in the park and the CSIs must find the killer. Blood and human tissue are found under Ashley Anders' nails and the DNA matches that of the CEO of the company that distributes her films – and he's a registered sex offender. Also, Calleigh discovers his answering machine audiotape on which he makes a threat against Ashley. However, there is an accident back at the lab with this crucial piece of evidence and Delko was the last person to handle it. Now, IAB's Rick Stetler is put on the case, much to Horatio's dismay, as the CSIs try to uncover further evidence in order to find the girl's killer.

A woman is killed during a posh party at an exclusive waterfront estate when a man opens fire on the proceedings from a cigarette boat. When a former con is arrested, he acts as his own lawyer and proves to be smarter than he appears. Complicating matters is the fact that the leading witness in the case is the dead woman's 10-year-old son, whom Horatio wants to protect, refusing to let him testify.

The wife of a famous baseball player is brutally killed in her home and her philandering husband is charged with the crime. The jury on the case, as well as the accused and his defense, visits the house to examine the crime scene, but when the lights are dimmed, as they were when the victim was killed, and then turned back on, the ball player is found dead with a meat clever in his back and a note that reads "guilty." Now, as Horatio and the team find that the husband's defense team tampered with the crime scene, they must examine the evidence to find the couple's killers. Meanwhile, Horatio gets a call from Yelina, who tells him that her son, Ray, Jr., is missing.

The team investigates a modern-day piracy off the coast of Miami after six bodies are discovered floating in the ocean tied together by rope. Horatio suspects that a ship was hijacked with some of the crew killed and then dumped overboard. Evidence suggests that other crew members might have escaped on a life raft. Using radar and GPS technology, the CSIs find survivors but their stories don't match. Now, Horatio and the team must learn what really happened out in the ocean as they find themselves investigating the seamy underbelly of Miami's militias and arms dealers.

During a routine traffic stop, a police officer is murdered and now Horatio and the team must track down the killer. The only witness to the murder is a civilian who was doing a ride-along with the officer, but who is now missing. Roadside evidence leads the CSIs to Missy Marshall, a teenage girl who was with the killer at the time of the murder. However, as the team searches for the civilian and the killer, they find that Missy may have been more involved with killer and the shooting than she is admitting. Meanwhile, Horatio and Rebecca's relationship is in jeopardy when they don't see eye to eye on a case.

Someone uses a laser light to blind a pilot and bring down a jet, which carries $1.2 billion in checks to be delivered to banks on the eastern seaboard. The crime scene evidence reveals a victim, a young fundraising socialite, who was inside the plane but killed prior to the crash. Now, although the team has little to work with since the victim's wealthy family is opposing an autopsy, Horatio must follow the money trail. Meanwhile, Calleigh works on the case with her ex-boyfriend, Detective Hagen, and their romantic history could cause problems for both of them.

After a bitter custody battle, shots are fired outside the courthouse. Bullets fly and the target is the little girl's mother. Horatio goes after the father, who he suspects may not be the girl's biological father after all. However, when the mother's shady past is uncovered, the team finds that she has a lot of enemies who would like to take a shot at her. Meanwhile, Calleigh's father returns to the crime lab for her guidance but for an unexpected reason.