The episode picks up straight where "One of Our Own" left off. Horatio and Delko have arrived in Rio de Janeiro to hunt down Antonio Riaz, who ordered the hit on Marisol. The problem is that Horatio can't stop thinking about his late wife, and Brazilian authorities aren't being very cooperative. While there, Horatio runs into Yelina and finds out that Raymond is missing again. Ray Jr., now fourteen, teams up with Brazilian authorities and will stop at nothing to bring his father home safe, until Horatio learns the terrible truth... Raymond is already dead. Now Horatio must stop his nephew from getting himself killed trying to chase a ghost.

Calleigh is run off of the road in to a canal and causes freshly collected evidence to be compromised. The team must work to find new evidence, as most of the water-damaged evidence is unusable.

The CSI’s investigate the murder of a male model and have to figure out the inner workings of the modeling world in order to find his killer.

The body of a local politician is found in an empty house. The entire neighborhood was upset that he was backing the use of eminent domain, allowing the government to force them out of their homes.

When strange accidents occur in the lab, the CSI team is spooked during a death investigation involving voodoo. As Halloween is near everyone starts to think that the lab is cursed.

After an accident where the driver was decapitated during a dangerous stunt, the evidence leads the CSI’s to believe it was more than an accident. While gathering the evidence, the CSI’s find they must go into the world of “sideshows.”

A murder and kidnapping becomes personal when DNA from a crime scene reveals that Natalia’s sister Anya is one of the kidnapped women they are looking for. The team finds a safe full of photos of missing women and they must find the photographer who was using his camera to lure the unsuspecting women.

After a young woman is found dead shortly after she was auctioned off for charity, the team finds that the woman was trying to uncover the true nature of the event’s host. As the team delves deeper into the investigation they soon discover a larger plot that could put Miami in danger.

A Marine recruiter is found dead on a civilian shooting range with various bullet holes in him, but there is no blood at the scene. The investigators uncover that the victim was dead before he was shot and that his body was pulled onto the range. As the case advances, Horatio determines the murder may be tied to the death of a marine in Iraq who was killed in combat. Likewise, Natalia is shocked to learn that Nick asked Valera out and that she accepted.

When terror suspect Sonya Barak is targeted by her own people for assassination, she goes on the run, and Horatio sets out to capture her, both to protect her and bring her to justice.

ניק נרצח בדירתו, ונטליה נעצרת אחרי שהראיות בזירה מצביעות עליה כחשודה המרכזית.

פרנק דורך בטעות על מוקש בעת חקירת זירת פשע, בעוד הוראשיו וצוות המומחים מנסים לנטרל אותו.

חייהם של שני חוקרי זירת הפשע נמצאים בסכנה כאשר אויב וותיק של הוראשיו חוזר לתמונה.

אחרי אירועי האמבוש במגרש המכוניות, דלקו נאבק על חייו לאחר שהוא נורה בראשו.

הוריה של שמרטפית בשכונה יוקרתית נמצאים מתים. החקירה מובילה את החוקרים לכיוונים מפתיעים ולרופא עם סוד אפל.

היחידה חוקרת את מותו של אדם שהותקף ע"י דוב, ומגלה שהמפגש הקטלני לא היה אקראי.

יזם נדל"ן עשיר נרצח באחוזה בעת שמתקיים בה אירוע התרמה למען בית חולים לילדים המאורגן על ידי אשתו.

הצוות חוקר את נסיבות מותו של אדם שנמצא מקורקף בקרבת קזינו הנמצא בשמורת אינדיאנים.

הוראשיו חוקר רצח של כוכב קולנוע במרכז גמילה למפורסמים.

When the mistress involved with the husband in Miami's ugliest divorce battle is found to have been killed the divorce battle intensifies and the body count rises.

When one of Horatio's team lets their personal problems contaminate the investigation involving a spurned ex-lover, Horatio has to fire that team member.

After the murder of a suspected carjacker the team discovers that he may have been involved with a formidable drug lord and was suspected of drug running off Miami's shores.

There's a serial killer on the loose marking all of his victims with a Y on their chests and one or more of the csi's lives are in danger in this season 5 finale