The whole team investigates the crime scene of an indoor amusement park when a young girl is found dead in the bathroom. They must track down the relentless man responsible for the heinous crime quicker than usual, as everyone on location has been detained until they can be cleared. What looks to be like a regular attempted kidnapping turns out to be much more than any of the detectives had bargained for.

Horatio, Speedle and Calleigh root through the evidence in the homocide of a strange, and unorthodox college professor when they find him tied to a tree. Elsewhere, Delko and Megan investigate a car found in the water with a dead body in the trunk, and immediately suspect an insurance scam.

A nude man is found tied to his bed, having suffocated on a rag stuffed in his mouth while he was being sexually assaulted. Meanwhile, while investigating the murder of a crematorium owner, the CSIs discover dozens of bodies that were never cremated.

A dead junkie is found on a Miami street with a broken neck and a wad of cash in his hand. When the body is taken to the lab, Alexx notices that the victim's right hand is burned down to the muscle, even though it wasn't like that when he was found. It's deduced that he was exposed to radioactive material. The investigation leads Horatio to an environmental lawyer involved in radiation cases. Shortly thereafter, she learns that she is being eaten up inside by the deadly substance and has only days to live, but she doesn't know how she ingested it or who gave it to her.

Horatio is approached by a parolee he helped put away several years ago, who begs for his assistance in finding his missing teenage son. As the investigation gets underway, Horatio discovers that the boy may be planning a deadly assault at his high school. Meanwhile, as Speedle investigates a man's death, the victim's flirtatious girlfriend, who was there when he died, tries to play on Speedle's obvious attraction to her.

The team investigates the deaths of two college students who were in Miami on spring break. The first is a teenage girl found dead on a beach with her neck broken and human bite marks on her legs. The second is a young man found in the bottom of a hotel swimming pool who apparently died before he hit the water.

Speedle and Delko are present when a trendy nightclub catches fire, apparently from a DJ's pyrotechnics display, killing sixteen people and injuring dozens of others. But the ensuing investigation reveals it may have been arson to cover up a murder. Meanwhile, Horatio probes the death of a prostitute whose body is found in the bathroom of a judge's home and evidence suggests that she was in the club during the fire.