The whole team investigates the crime scene of an indoor amusement park when a young girl is found dead in the bathroom. They must track down the relentless man responsible for the heinous crime quicker than usual, as everyone on location has been detained until they can be cleared. What looks to be like a regular attempted kidnapping turns out to be much more than any of the detectives had bargained for.

Horatio, Speedle and Calleigh root through the evidence in the homocide of a strange, and unorthodox college professor when they find him tied to a tree. Elsewhere, Delko and Megan investigate a car found in the water with a dead body in the trunk, and immediately suspect an insurance scam.

A dead junkie is found on a Miami street with a broken neck and a wad of cash in his hand. When the body is taken to the lab, Alexx notices that the victim's right hand is burned down to the muscle, even though it wasn't like that when he was found. It's deduced that he was exposed to radioactive material. The investigation leads Horatio to an environmental lawyer involved in radiation cases. Shortly thereafter, she learns that she is being eaten up inside by the deadly substance and has only days to live, but she doesn't know how she ingested it or who gave it to her.

The investigation into a drug heist offers brief glimpses into the private lives of the CSIs, whose nerves are on edge when they become suspects in the crime they're trying to solve. A police convoy headed across town includes an unmarked truck filled with confiscated drugs being taken to an incinerator to be destroyed. The trip ends abruptly when thieves hijack the vehicle, kill its driver and shoot Speedle, who was riding shotgun. It's hard for Horatio when the media draw comparisons to a similar case several years ago in which his brother, an undercover cop, was killed. But it's worse for his team when Internal Affairs decides that one of them tipped off the robbers about the delivery.

A man and his wife are trying to drive out of a hurricane's fury when they strike and kill a man in the blinding storm. Horatio finds that the lack of impact wounds on the victim's knees suggest that he struck the car as opposed to the car striking him. Meanwhile, in a seemingly unrelated case, Horatio finds another victim of the hurricane impaled on a fence. However, as the CSIs uncover the scattered remains of the post-storm evidence, it seems that these two cases may have a deadly connection. Meanwhile, after Calleigh witnesses a man looting a house, she realizes that she's got another case on her hands when she finds his ex-wife inside shot to death.