Un gruppo di alieni invasori svegliati accidentalmente anni fa da un astronauta in missione su Marte, attaccano la terra, Superman e Batman salvano J'onn J'onnz il quale contatta telepaticamente Wonder Woman, Alata, Flash, e Lanterna Verde per impedire l'invasione. Superman propone dunque di formare un gruppo e monitorare il loro pianeta dalla "Torre di controllo" costruita da Batman (utilizzando il budget della Wayne Aerospace's) e da allora prendono il nome di Justice League.

No man escapes the Manhunters.' An alien court sends the Manhunters to bring Green Lantern back for prosecution on the charge of genocide, and the League gets involved.

Believing that Green Lantern is receiving an unfair trial, the Leaguers investigate, while GL's superiors, the Guardians of the Universe, enter as witnesses. But the whole trial may be a ruse.

When Aquaman, ruler of Atlantis, decides he has had enough of the surface-dwellers trespassing in his ocean, the Justice League tries to smooth things over. Aquaman takes Superman's advice and arrives in New York City to speak to the World Assembly, but it soon becomes apparent that he may have been right about the surface-dwellers all along.

Betrayed by his own subjects, Aquaman and the League fight to save Atlantis, the world, and Aquaman's own son against his half-brother Orm's coup.

Wonder Woman returns to Paradise Island to make up with her mother for her rapid departure, only to find the Amazons transformed to statutes. The sorcerer Felix Faust is holding them hostage to force Diana to recover three ancient artifacts.

The League fight to save Paradise Island and Wonder Woman's own mother from Felix Faust and Lord Hades.

Superman and J'onn are taken prisoner during a rescue mission gone bad, and Superman is forced to compete in a gladiatorial tournament on a distant world while Hawkgirl and Green Lantern try to rescue them.

Fight promoter and new contestant Mongul instructs Superman to throw the fight against him, or he'll destroy the enslaved Draaga's home planet.

When the Flash is mind-controlled into committing a crime, he and Green Lantern work to clear his name and uncover a sinister scheme.

When Gorilla Grodd mentally enslaves a city of humans and prepares to destroy Gorilla City, Green Lantern and Flash try to defeat him while the other Leaguers move to help the ape civilization.

A renegade Amazon, Aresia, leads a new incarnation of the Injustice Gang to accumulate the components for a bio-weapon.

When the male Leaguers are infected by the same disease sweeping Earth, Wonder Woman and Hawkgirl must defeat Aresia and find a cure.

An explosion throws four Leaguers into an alternate dimension where they meet their childhood comic book heroes...the Justice Guild!

The League aid the Justice Guild against their arch-nemeses while trying to unravel the secrets of the Guild's world.

Exposed as a criminal, sentenced to prison, and terminally ill due to long term kryptonite exposure, Lex Luthor escapes and assembles a supervillain team consisting of Cheetah, The Shade, Solomon Grundy, Star Sapphire, Copperhead, and Ultra-Humanite to take on the Justice League, calling themselves the Injustice Gang. The Joker also becomes part of the team, but on his own choice. However, this gang proves short-lived as its major weakness proves no match for Batman's wiles.

Exposed as a criminal, sentenced to prison, and terminally ill due to long term kryptonite exposure, Lex Luthor escapes and assembles a supervillain team consisting of Cheetah, The Shade, Solomon Grundy, Star Sapphire, Copperhead, and Ultra-Humanite to take on the Justice League, calling themselves the Injustice Gang. The Joker also becomes part of the team, but on his own choice. However, this gang proves short-lived as its major weakness proves no match for Batman's wiles.

Morgaine and Mordred get the Stone and plan to transform England and restore it to its medieval glory.

An old friend of John Stewart's is inadvertently turned into a freak capable of altering his molecular structure, separating him from his girlfriend and pitting him against the League.

The League battle Metamorpho but soon discover that his future father-in-law, Simon Stagg, poses the true menace.

When the present is altered, the Justice League must travel back in time to World War II to restore history.

A separate League struggle against the Nazis and determine who is responsible for the Axis' technological advances.

Wonder Woman and Steve Trevor survive the attack and trick the Germans into believing that the communicator was destroyed. GL and Easy Co. find the runaway and discover that Vandal Savage plans to use jet aircraft to invade America. GL boards and tries to stop Vandal's plane while Hawkgirl, Superman, and Flash try to intercept the flight with J'onn's help. With the aid of the Blackhawks and Flash notifying the U.S. Navy, the German flight is shot down and Vandal apparently is killed. The JLA return to the present to find everything restored and Wonder Woman visits a now elderly Steve Trevor in the restored present.