It's the first day of school at Acme Looniversity. Babs and Buster Bunny meet their new friends, Sweetie Bird, Hamton J. Pig, and Plucky Duck.

Babs realizes Acme Loo's school paper has closed so she starts a new one with her pal Sweetie. But when Plucky starts a gossipy tabloid to compete against them, which paper will come out on top?

Buster and Sweetie join the Tooney Ball team during Electives Week while Babs and Plucky tackle the basics in Anvils 101, leaving Hamton on a journey to fix his indecisiveness.

Buster meets his nemesis, Montana Max, and must apply a new lesson from Bugs about drag to keep the Loo Bru from demolition.

It's Prank Week at Acme Loo and our pals get into escalating shenanigans trying to out prank their rival, Aqua Loo.

Hamton gets into medical school but soon realizes it's not at all what he imagined. Buster desperately tries to find a way to bring his pal back to Acme Loo.

Babs and Buster are excited to get college jobs, but can they stand the heat cooking for the school chef?

Buster finds a cloning machine at Wile E. Coyote's yard sale that he uses to make another Buster, Babs and Sweetie snag a time machine that they use to open a vintage clothing store.

Babs is excited to be the first student director of the annual toon showcase, but she quickly learns it won't be easy as she thought. Meanwhile, with the help of his friends, Hamton learns to shine in the spotlight.

Plucky goes home with Babs and Buster for Spring Break and quickly becomes the new star of Burrowville, while Hamton and Sweetie embark on the adventure after accidentally missing their train stop.