The Frank Skinner Show was a television chat show hosted by comedian Frank Skinner, which lasted nine series on British television between 1995 and 2005.

As well as celebrity interviews, the shows included an initial stand-up routine, various sketches throughout the episode and usually concluded with a comedic song featuring Frank and the guest stars. The Frank Skinner Show became notorious over the years for the unconventional nature of the interviews, including some shocking revelations from the guests. The programme ended in 2005 after nine series.

It was screened on BBC One from its first episode on 10 September 1995 until 3 June 1999.

In 2000, the show moved to ITV. The programme was nominated for a Royal Television Society Award in 2001.