Merv Griffin's Crosswords is an American game show based on crossword puzzles. The show was created by its namesake, Merv Griffin, who died shortly after beginning production on the series. Ty Treadway was the host, and Edd Hall was the announcer.

The series ran in daily syndication from September 10, 2007 and aired first-run episodes until May 16, 2008. Reruns continued to air in some markets until September 4, 2009, and can now be seen on FamilyNet, ALN, and RTV.

The show was produced by Yani-Brune Entertainment and Merv Griffin Entertainment, and was distributed by Program Partners.