시즌 정규 출연진 11

1. 

   Dominic West

   Jimmy McNulty

2. 

   Lance Reddick

   Cedric Daniels

3. 

   Sonja Sohn

   Kima Greggs

4. 

   Wood Harris

   Avon Barksdale

5. 

   Wendell Pierce

   Bunk Moreland

6. 

   Idris Elba

   Stringer Bell

7. 

   Deirdre Lovejoy

   Rhonda Pearlman

8. 

   Andre Royo

   Bubbles

9. 

   Frankie Faison

   Ervin Burrell

10. 

    John Doman

    William Rawls

11. 

    Lawrence Gilliard Jr.

    D'Angelo Barksdale

특별출연 20

1. 

   Michael Kenneth Williams

   Omar Little

2. 

   Delaney Williams

   Sgt. Jay Landsman

3. 

   Michael B. Jordan

   Wallace

4. 

   Al Brown

   Maj. Stanislaus Valchek

5. 

   Wendy Grantham

   Shardene Innes

6. 

   Seth Gilliam

   Detective Ellis Carver

7. 

   Domenick Lombardozzi

   Detective Thomas 'Herc' Hauk

8. 

   J.D. Williams

   Preston 'Bodie' Broadus

9. 

   Hassan Johnson

   Roland 'Wee-Bey' Brice

10. 

    Doug Olear

    FBI Spec. Agent Terrance 'Fitz' Fitzhugh

11. 

    Richard DeAngelis

    Maj. Raymond Foerster

12. 

    Michael Salconi

    Detective Michael 'Sanny' Santangelo

13. 

    Clarke Peters

    Detective Lester Freamon

14. 

    Jim True-Frost

    Detective Roland 'Prez' Pryzbylewski

15. 

    Corey Parker Robinson

    Detective Leander Sydnor

16. Tom Quinn

    Det. Patrick Mahon

17. Nat Benchley

    Det. Augustus Polk

18. 

    Tray Chaney

    Malik 'Poot' Carr

19. Brandon Price

    Anton 'Stinkum' Artis

20. 

    Tony D. Head

    Maj. Bobby Reed

제작진 11