Elenco Principal da Temporada 4

1. 

   Seth MacFarlane

   Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Tom Tucker (voice)

2. 

   Alex Borstein

   Lois Griffin / Tricia Takanawa / Loretta Brown / Barbara Pewterschmidt (voice)

3. 

   Mila Kunis

   Meg Griffin (voice)

4. 

   Seth Green

   Chris Griffin (voice)

Convidados Especiais 13

1. 

   Johnny Depp

   Edward Scissorhands (voice)

2. 

   Fiona Gubelmann

   Lois' New Friend (voice)

3. 

   Max Charles

   Kid (voice)

4. 

   Adam West

   Adam West (voice)

5. 

   Hunter Gomez

   Justin Bieber (voice)

6. 

   Sara Fletcher

   Lois' New Friend (voice)

7. 

   Fred Tatasciore

   Bieber's Bodyguard (voice)

8. 

   Steve Callaghan

   Grocery Store Employee / Stagehand (voice)

9. 

   John G. Brennan

   Man #2 (voice)

10. Patrick Meighan

    (voice)

11. 

    Alec Sulkin

    (voice)

12. 

    Chris Cox

    Man (voice)

13. 

    Patrick Warburton

    Joe Swanson (voice)

Equipa Técnica 2