When Steve brings home a permission slip to take sex ed at school, Stan flips out and demands to teach it himself. However, after Stan unrealistically explains the birds and the bees to Steve, he gets into an accident that causes him to take matters into his own hands. Meanwhile, Roger becomes a bartender in hopes of making something of himself.

When the CIA organizes a father-son baseball game, Stan is determined to show his co-workers that his son is masculine and athletic. Unfortunately, Steve is a geek, so Stan decides to lie and ditches him. But after getting a taste of his own treatment at work, Stan turns to Steve and his sci-fi knowledge to help capture a cyber-terrorist. Meanwhile, Roger goes incognito in a desperate attempt to interact with humans.

When Stan's father passes away, Stan reveals his real father is actually Jack Smith, a super suave spy. Jack convinces Stan to quit the CIA and work with him at the Scarlet Alliance, an ultra-secret spy group. Francine is upset with Stan, who is busy training with Jack for a mission involving uranium, artwork and terrorists. But when the FBI shows up at the Smiths' house looking for an international jewel thief, Francine suspects Jack is the fake.

Stan has to throw a party for his boss and assumes his wife Francine will do all the work, but she refuses. With Stan as party planner, the event turns into a disaster. As a result, Stan's boss relocates Stan and his family to Saudi Arabia, where they quickly get a taste of life on foreign ground. As American and Arabian social norms clash, gender wars heat up.

Stan har blitt utstasjonert i Saudi-Arabia og selv nyter det mannsdominerte samfunnet, men resten av familien sliter med de kulturelle forskjellene.

Francine er lei av at Stan og Hayley krangler om våpenkontroll og insisterer på at de tilbringer en hel dagen sammen slik at de kan komme nærmere hverandre.

Steve blir en berømt forfatter og hele familien blir lidenskapelig opptatt av Steves nye kjendisstatus.

Francine blir bergtatt av en gruppe damer som ser ut til å ha alt. Hun prøver å imponere dem slik at hun selv kan bli en av dem, men så viser det seg at de slett ikke er så perfekte som først antatt.

Stan og Roger har begge en tøff dag og ender opp med å slåss, men slåsskampen gjør på magisk vis at de bytter plass med hverandre og begge får kjenne hvordan det er å gå i den andres sko.

Stan får en heftig bonus på jobb og kjøper alskens nye duppeditter, men er ikke lydhør overfor Francines store drøm om en egen kiosk. Skuffet over Stans manglende støtte tar Francine og åpner en muffinsbutikk på egenhånd og Stan får kjenne på hvordan livet er uten en hjemmeværende kone.

Because of a past incident at his own prom, where he was lured into a dance with the homecoming queen only to have a pile of pigs dropped on him, Stan wants revenge by showing off that he married a homecoming queen, Francine. A proud Stan accompanies Francine to her reunion, but when they find out that two ballots were lost and that Francine didn’t actually win the crown, Stan is devastated. Meanwhile, a dejected Steve is “saved” by a pizza delivery man with a Messianic message.

When Stan goes to Atlantic City for a bachelor party and is shunned by his so-called best friend, Roger steps in and becomes Stan's new sidekick. Their friendship goes to a whole new level, but when they return home and face Francine, Stan realizes that what happens in Atlantic City doesn't necessarily stay there. Meanwhile, Hayley and Steve team up to break up a good-looking couple.

Stan wants Steve to be popular and goes to desperate measures giving him steroids to make him bigger, better, and part of the in-crowd at school. But when the steroids have an unexpected side effect, Steve gets a lot more attention than anyone expected. Meanwhile, after Hayley makes a movie about Francine's life as a housewife, Francine is determined to start a new career as a doctor.

After Steve shows a lack of interest in Stan's job, Stan replaces him with Barry, Steve's malicious friend. Barry frames Steve to eliminate him from the household, but when Steve discovers Barry's weakness, he relies on his CIA skills to save the family. Meanwhile, Roger takes an impressive keg-stand and uses it to become a fraternity brother.

When Francine's birthday brings back haunting memories of a celebrity film moment stolen by George Clooney, Francine's new dream is to destroy the star. But when she tries to win Clooney's heart with the intention of breaking it, Stan actually falls for him and sabotages the plan. Meanwhile, back at home, Roger builds a vineyard and starts up a private sweat shop of foster children.