Elenco Principal da Temporada 5

1. 

   Seth MacFarlane

   Stan Smith / Roger (voice)

2. 

   Wendy Schaal

   Francine Smith (voice)

3. 

   Rachael MacFarlane

   Hayley Smith (voice)

4. 

   Scott Grimes

   Steve Smith (voice)

5. 

   Dee Bradley Baker

   Klaus (voice)

Convidados Especiais 8

1. 

   Ira Glass

   Ira Glass (voice)

2. 

   Kathryn Hahn

   Luli (voice)

3. 

   Patricia Lentz

   911 Operator (voice)

4. 

   Adam Devine

   Christoff (voice)

5. 

   Phil LaMarr

   Artemis (voice)

6. 

   Mike Barker

   Terry Bates (voice)

7. 

   Phill Lewis

   Duper (voice)

8. 

   Patrick Stewart

   Avery Bullock (voice)

Equipa Técnica 3