Live With Chris Moyles was a short-lived British comedy chat show on five, which aired weekdays at 7pm. The show was filmed in front of a live audience in a bar in London.

The show consisted of Moyles' unique take on the day's news, interactive fun and games with competitions such as 'Dancing Letters', and celebrity guests dropping in for a pint and a chat.

Chris Moyles talks about this show in The Difficult Second Book. In it he says how after a show he had a conversation with the producer, radio DJ and owner of UMTV, Chris Evans. During the conversation Moyles said he didn't like the way the show was being made and that anyone could present it, and wanted to give it a more unique style for his personality. After this Evans avoided Moyles until the end of the shows run. Although the show was commissioned for a second series, whilst Moyles was on holiday his agent was sent a press release saying that Christian O'Connell was the new host of the show and that Moyles was moving on to do other projects for Five.