Last season ended with Beckett wrestling over whether to take a high-profile job in DC -- a dilemma made more complicated when Castle proposed to her. In the Season 6 Premiere of "Castle," Castle and Beckett will deal with the consequences of their decisions against the backdrop of a high-stakes investigation.

Continuing from the season premiere episode, Beckett races against time to find a stolen toxin capable of killing tens of thousands of people. To make matters worse, Castle was exposed, leaving him with less than 24 hours to live.

With Beckett still in D.C., Castle and the boys investigate the murder of former child star Charlie Reynolds, who rose to fame playing the lovable nerd on an early 90s High School sitcom. But the case takes a turn for the strange when Agents Beckett and McCord arrive from Washington to take over the investigation, creating competitive tension in the precinct. But why would a washed-up actor's death warrant Federal scrutiny? Whatever the reason, Beckett and McCord aren't telling. Meanwhile, Castle has to contend with a new face at the 12th, NYPD Detective Frank "Sully" Sullivan.

A desperate young murder suspect, Emma Briggs, takes hostages at gunpoint then mysteriously insists that she will only negotiate with one person: Richard Castle.

A grisly murder investigation leads Castle and Beckett to a suspect who claims he's traveled back in time to stop terrible events from unfolding, events that will change the course of human history. Is he simply a deluded killer, or is it possible that he's telling the truth?

As Castle and Beckett investigate the ritualistic murder of a young woman, they find strange symbols in the victim's apartment; Castle struggles with Alexis' decision to move in with Pi.

When a pop star is found dead in an alley, Beckett and Castle look into her hard-partying lifestyle; a shocking revelation rocks the investigation.