Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Wolowitz tries to pick his astronaut nickname.

The fifth season ends with Howard and Bernadette deciding to get married before his NASA mission, causing the gang to scurry into overdrive in an effort to stage the wedding. NASA astronaut Mike Massimino has a cameo as himself.

When Sheldon learns that Penny is thinking about breaking up with Leonard, he tries to intervene. Meanwhile, in space, the other astronauts pick on Howard.

When Wolowitz returns from space, he doesn’t get the hero’s welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.

Leonard buys a dining room table and it causes Sheldon to reevaluate the changes in his life. Meanwhile, Wolowitz is offered a chance to go back to space and Bernadette struggles with whether or not to encourage him.

Wolowitz feels nervous when he is asked to throw the first pitch at a Los Angeles Angels game. Penny and Leonard want to prove Sheldon wrong after he says he and Amy are the better couple.