When NASA moves up Howard's mission, he must face his fears and Bernadette's dad, thus putting the wedding plans in jeopardy. Meanwhile, Leonard says something surprising to Penny in the bedroom.

The fifth season ends with Howard and Bernadette deciding to get married before his NASA mission, causing the gang to scurry into overdrive in an effort to stage the wedding. NASA astronaut Mike Massimino has a cameo as himself.

When Amy gets sick, Sheldon tries to nurse her back to health; Wolowitz and his father-in-law plan a fishing trip.

Sheldon protests when the gang drags him to Mrs. Wolowitz’s house for Thanksgiving. Meanwhile, Penny and Leonard must deal with a mistake from her past.

Leonard buys a dining room table and it causes Sheldon to reevaluate the changes in his life. Meanwhile, Wolowitz is offered a chance to go back to space and Bernadette struggles with whether or not to encourage him.

Wil Wheaton interviews Sheldon for a Star Trek documentary where he reveals the ring and his plan to propose to Amy. Bernadette wants to start renovating the house and the topic of starting a family together with Howard is brought up.