Stała obsada sezonu 12

1. 

   Ellen Pompeo

   Meredith Grey

2. 

   Chandra Wilson

   Miranda Bailey

3. 

   Sandra Oh

   Cristina Yang

4. 

   James Pickens Jr.

   Richard Webber

5. 

   Katherine Heigl

   Izzie Stevens

6. 

   Justin Chambers

   Alex Karev

7. 

   T.R. Knight

   George O'Malley

8. 

   Sara Ramirez

   Callie Torres

9. 

   Isaiah Washington

   Preston Burke

10. 

    Patrick Dempsey

    Derek Shepherd

11. 

    Eric Dane

    Mark Sloan

12. 

    Kate Walsh

    Addison Montgomery

Goście specjalni 20

1. 

   Diahann Carroll

   Jane Burke

2. 

   Christopher Lowell

   William 'Dell' Parker

3. 

   Bellamy Young

   Kathy

4. 

   Jeff Perry

   Thatcher Grey

5. 

   Becky Wahlstrom

   Lisa

6. 

   Tim Daly

   Dr. Pete Wilder

7. 

   Stephanie Niznik

   Carol

8. 

   Mare Winningham

   Susan Grey

9. 

   Raphael Sbarge

   Paul

10. 

    Elizabeth Reaser

    Jane Doe / Ava

11. 

    David Anders

    Jim

12. 

    Taye Diggs

    Sam Bennett

13. 

    Merrin Dungey

    Naomi Bennett

14. Cameron Watson

    Rick

15. 

    Gary Hershberger

    Doug

16. 

    Mary Joy

    Voice (voice)

17. 

    Garon Grigsby

    Keith

18. 

    Paul Adelstein

    Cooper Freedman

19. 

    Amy Brenneman

    Violet Turner

20. 

    Jane Clark

    Nurse

Ekipa 3