Pravidelné obsadenie série 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liu

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Hosťujúce hviezdy 16

1. 

   Bob Gunton

   Frederick Wentz

2. Kimberly S. Fairbanks

   Lisa Cooper

3. 

   Nora Murphy

   Jessi McNally

4. 

   Sathya Sridharan

   Amir

5. 

   Caprice Benedetti

   Italian Woman

6. 

   Luis Moreno

   Suited Detective

7. 

   Mike Keller

   Plainclothes Cop

8. 

   Jonathan Sale

   Team Leader

9. 

   Erica Bradshaw

   Nurse

10. 

    Paco Lozano

    Driver

11. 

    Marc Webster

    Guard #1

12. 

    James Frain

    Odin Reichenbach

13. 

    Jordan Gelber

    Dr. Eugene Hawes

14. 

    Rachael Holmes

    Antonia

15. 

    Tim Guinee

    Agent Dean McNally

16. 

    Michael Hayden

    Assistant District Attorney Grassley

Štáb 2