Πρωταγωνιστές του κύκλου 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liu

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Γκεστ σταρ 10

1. 

   Brett Dalton

   Ryan Hayes

2. 

   Trieste Kelly Dunn

   Sophie Bishop

3. 

   Wayne Wilcox

   Drew Bishop

4. 

   Summer Sveinson

   Bethany Marshall

5. 

   Geoffrey Owens

   Vernon Fisk

6. 

   Trevor Van Uden

   Sammy Olivetti

7. 

   Ricky Garcia

   Ramon

8. 

   J. Oscar Simmons

   Foreman

9. 

   Desmond Harrington

   Michael Bowen

10. 

    Jordan Gelber

    Dr. Eugene Hawes

Συντελεστές 6