Pravidelné obsadenie série 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liu

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Hosťujúce hviezdy 10

1. 

   Nelsan Ellis

   Shinwell Johnson

2. 

   Jeremy Burnett

   Duane

3. 

   Emily Dorsch

   Dr. Franny Krieg

4. Jake Brinskele

   Ethan Moore

5. 

   William Ragsdale

   Patrick Moore

6. Darlesia Cearcy

   Pharmacist

7. 

   Charlie Pollock

   Lee Fisk

8. Stephanie Jean Lane

   Katie

9. Wendell B. Franklin

   DEA Agent Ritter

10. 

    Chris McKinney

    Detective Guzman

Štáb 5