Stała obsada sezonu 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liu

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Goście specjalni 11

1. 

   Skipp Sudduth

   William Ziff

2. 

   Virginia Madsen

   Paige

3. 

   Jordan Gelber

   Dr. Eugene Hawes

4. 

   Malcolm Gets

   Malcolm Busquet

5. 

   Jackie Hoffman

   Female Activist

6. 

   Brian Avers

   Elliot

7. Rebecca S'Manga Frank

   Passerby

8. 

   Edelen McWilliams

   Alan's Lawyer

9. 

   Jon Shaver

   Town Car Driver

10. 

    Hadi Tabbal

    Jason Leary

11. Cullen Wheeler

    Derek O'Neal

Ekipa 2