Stała obsada sezonu 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liu

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Goście specjalni 12

1. 

   Rhys Ifans

   Mycroft Holmes

2. 

   William Sadler

   Ian Gale

3. 

   Margaret Colin

   Natalie Gale

4. 

   Casey Biggs

   Alan Becker

5. 

   Kieran Campion

   Ray McKibben

6. 

   Mark Zeisler

   Arthur Watkins

7. 

   Johanna Day

   Maureen Tyler

8. 

   Kersti Bryan

   Haley Tyler

9. 

   Elliot Villar

   Christian Suarez

10. 

    Stephen Friedrich

    Pet Groomer Employee

11. 

    Mike Masters

    Security Guard

12. 

    Jordan Gelber

    Dr. Eugene Hawes

Ekipa 22