Πρωταγωνιστές του κύκλου 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liu

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Γκεστ σταρ 6

1. 

   Rhys Ifans

   Mycroft Holmes

2. 

   Ralph Brown

   Tim Sherrington

3. 

   Emily Bergl

   Marion West

4. 

   Jim Norton

   Sir James Walter

5. 

   Tony Sheldon

   British Doctor

6. 

   Jordan Gelber

   Dr. Eugene Hawes

Συντελεστές 5