Pravidelné obsadenie série 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liuová

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Hosťujúce hviezdy 9

1. 

   Thomas Jay Ryan

   Ken Whitman

2. 

   Wayne Duvall

   Duke Landers

3. 

   Joseph Siravo

   Anthony Pistone

4. 

   Tom Guiry

   Brent Garvey

5. 

   David Mogentale

   Charles Augustus Milverton

6. Randy Louis Swiren

   Stuart Bloom

7. Portia Reiners

   Eva Whitman

8. 

   Russell G. Jones

   Attorney

9. 

   Ato Essandoh

   Alfredo Llamosa

Štáb 17