Elenco Principal da Temporada 4

1. 

   Jonny Lee Miller

   Sherlock Holmes

2. 

   Lucy Liu

   Joan Watson

3. 

   Jon Michael Hill

   Marcus Bell

4. 

   Aidan Quinn

   Thomas Gregson

Convidados Especiais 14

1. Michael Den Dekker

   Detective

2. 

   Josh Hamilton

   Drew Gardner

3. 

   Jim True-Frost

   Anson Samuels

4. 

   Geneva Carr

   Rebecca Burrell

5. 

   Andre Royo

   Thaddeus

6. 

   Roxanna Hope

   Callie Burrell

7. 

   Kenneth Tigar

   Philip Armistead

8. 

   Penny McNamee

   Vivian Tully

9. 

   Timothy Sekk

   Ken

10. 

    Victoria Cartagena

    Hope

11. Stephen Niese

    Anchor

12. 

    Jimmy Palumbo

    Security Guard

13. 

    Susan Pourfar

    Emily Hankins

14. 

    Ato Essandoh

    Alfredo Llamosa

Equipa Técnica 3