Oliver encounters a mysterious woman, Helena Bertinelli, daughter of mob boss Frank Bertinelli, who he can finally be himself with, but he soon comes to realize she's hiding dangerous secrets of her own. Helena is on her own personal mission of vengeance and Oliver is caught in the middle. Meanwhile, Tommy is blindsided by an unfortunate turn of events and turns to Laurel for support.

When a superhumanly strong thief robs a Queen Consolidated warehouse, Central City police scientist Barry Allen comes to Starling City to investigate the case. However, despite his close working relationship with Felicity, Oliver suspects that there's more to the young scientist than meets the eye. Meanwhile, Sin asks Roy to help investigate the disappearance of a friend. In the past, Oliver, Shado, and Sara try to get Slade to the submarine so they can use the serum to save his life.

After covering from a near-fatal drug overdose, Oliver begins hallucinating people from his past. Believing he's a liability, Oliver gives the information he has on Cyrus Gold to Quentin... which results in the deaths of several police officers. Meanwhile, Brother Blood captures Roy and uses him as a test subject for his new serum. In the past on the island, Ivo gives Oliver an impossible choice to make.