House uncovers a startling secret when he treats a teenage supermodel for heroin addiction. Meanwhile, Wilson hopes the increased leg pain in House's leg is an indication his leg nerves are regenerating.

After losing a bet with Wilson over a boxing match, House is convinced that his fighter has an underlying medical condition that cost him the fight. While he tries to prove it, he leaves his team alone to help a bomb scientist who suffered a seizure. Meanwhile, House may be experimenting with a new drug to help his leg pain.