Dr. Gregory House, a brilliant diagnostician but devoid of bedside manner, and his elite team of young medical experts rush to save the life of a kindergarten teacher who started speaking gibberish and passed out in front of her class.

Dr. House takes Cuddy's challenge to go off his painkillers for a week, but the effects of his withdrawal symptoms may put his patient in danger.

House and his team battle to diagnose a pregnant patient's life-threatening illness, prompting her to make the most emotional decision of her life, and Vogler is determined to fire House.

When a police officer with a gunshot wound to the head and uncontrollable laughter is admitted, House and the team are baffled. When Foreman begins showing the same symptoms, they race to determine the cause of the illness before Foreman's condition takes the same path.