With his diagnostic team gone, House tries to diagnose a young woman who survived an office building collapse. With the condition getting worse, Cuddy puts pressure on House to hire a new team, but instead attempts a differential diagnosis with help from the janitor.

House is secretly trying to treat a fighter pilot who is a candidate for NASA's astronaut training program. Her diagnosis will be the test to choose which ones of the 40 applicants are going to take the empty spots in his team.

The candidates are now two teams of five women and five men, competing on diagnosing and treating a wheelchair-bound man. Meanwhile House does experiments on himself to test what happens after death, and Foreman, at another hospital, is treating his team in a House-like manner.

House finds that some of his own fellowship students will do whatever it takes, when they deal with a woman who believes she can talk to the dead.

House deals with a patient who mirrors the personality of anyone he meets. Meanwhile, Foreman is put in charge of overseeing the fellowship candidates.

Based on practically no information and no medical history about a mystery patient sent by the CIA, House is using some unorthodox methods to diagnose and treat him. Meanwhile the remaining candidates are questioning Foreman's judgment.

A film crew and the candidates are following around House distracting him while he is trying to diagnose a teenager who suffers from a heart attack prior to a serious plastic surgery.

House treats a magician but comes to believe he's faking illness to cover up his own incompetence. Meanwhile, House pits the fellows against each other in his version of an immunity challenge.

Under Cuddy’s pressure to choose his team, House gives the candidates a case of a former punk rock star who is a drug user. Whoever diagnoses the patient is going to have a future as a member of House’s team.

A mother's sudden paralysis during a indoor rock-climbing incident leaves her daughter injured, and House's new team looking for a cure. Meanwhile, House organizes his new recruits' Secret Santa gift exchange... with a few twists of his own.

House and his team have to diagnose a case at a distance when a researcher at a South Pole base is taken ill.

House and his team must diagnose a Jewish bride who is taken ill at her wedding. However, House is more interested in analyzing Wilson's relationship with his new girlfriend.

House copes with a patient whose symptoms conceal a greater problem, but spends much of his time dodging Cuddy's orders to give performance reviews, and fighting with Amber over who gets to spend more time with Wilson.

House is convinced one of the actors on his favorite soap opera “Prescription Passion” has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands, but both the actor and House's own team dismiss House’s assessment and do not believe there is anything wrong with him.

A bus accident leaves House with serious head trauma and partial amnesia. He comes to believe that a patient on the bus had a life-threatening disease and struggles to recall who it was, and what they had.

In the aftermath of the bus accident, House struggles with his head injuries and short-term memory loss, and must deal with a concerned Wilson who believes his friend's health may be in danger.

In the aftermath of personal tragedy, Wilson resigns from the hospital... and from his friendship with House. Meanwhile, Thirteen struggles with her personal medical problems while helping treat an executive assistant with a similar situation to her own.

The team deals with an organ donor whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.

A painter's undiagnosed illness affects his work, and House and his team must look at the man's paintings to determine what's wrong with him.

While en route to his father's funeral, House must help the team with a differential diagnosis on a young Chinese girl who has collapsed under mysterious circumstances.

Thirteen brings her one-night stand to the hospital after the woman has a seizure. However, the woman admits she slept with Thirteen just so she could get to House and have him diagnose her condition. Meanwhile, House continues to pay Lucas to spy on Wilson.

An ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man's daughter grows ill as well, the team must provide a diagnosis before both die. Meanwhile, Cuddy adopts a newborn but when the birth mother displays a rash, she has to make a decision between putting the mother or daughter at risk.

The team must treat an agoraphobic who refuses to leave his house, and have to work around Cuddy, who is less than thrilled at having hospital equipment relocated. Meanwhile, House is plagued by an itch, and Cameron and Chase have relationship issues.

While Foreman takes on a pediatric case on his own, the rest of the team deals with a 16-year-old factory manager and emancipated minor who collapses at work. When Foreman's patient takes a turn for the worse, he's forced to question whether he can deal with the situation on his own, or if he needs House's help.

A gun-wielding man from the waiting room at the Princeton-Plainsboro clinic takes House, Thirteen and several patients from the waiting room hostage in Cuddy's office. The man claims to be sick with a long undiagnosed illness and demands medical attention from the best doctor in the hospital, threatening to kill any hostages necessary along the way.

The team takes on the case of a fitness guru on an all-natural diet who collapsed while filming a video. Meanwhile, Foreman conducts Huntington's Disease drug trials and Thirteen signs on as a subject, Cuddy is forced to move into House's office, and Kutner uses House's name to run an online medical-advice website.

House and his team deal with a bullied girl who collapses during her school's Christmas program. Meanwhile, Foreman and Thirteen grow closer during the Huntington's disease drug trials, House gives a patient a gift, the staff wonder who gave House a special gift, and Cuddy gets an unexpected gift.

House and the team try to diagnose a man living with severe, chronic pain; Thirteen and Foreman explore their complicated relationship; Cuddy discovers that caring for her baby leaves her with little time to run the hospital.

Cuddy decides to spend more time at home to take care of her newly adopted baby and passes some of her day-to-day responsibilities off to Cameron, including supervising House. Cameron is forced to play House’s games and becomes involved in a power struggle as he and the team take on the case of a Special Education teacher who collapsed after spitting up blood in the middle of class. As House tests Cameron’s tolerance for his extreme measures, the patient continues to fall ill and House insists the teacher’s seemingly inherent goodness is actually a pathology.

House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up her entire career in order to pursue her own personal happiness. Though the team struggles to understand how the woman could give up saving lives for the sake of her own contentment, each grapple with the pursuit of happiness (or lack thereof) in their own lives. As the patient’s condition continues to worsen, so does Thirteen’s as she begins to suffer serious and life-threatening reactions to the experimental Huntington’s Disease clinical trial. Meanwhile, Cuddy attempts to make House’s life miserable for him in retaliation for his part in her own unhappiness.

When a priest who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep, he is admitted to the ER. House takes on the case as a distraction for the team while he confronts Foreman and Thirteen about their relationship. The team soon learns the priest had been involved in a molestation scandal that caused him to lose his faith. However, just as they are about to dismiss his case, the patient’s condition takes a drastic turn for the worse, and House grapples with his past and his belief

A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy's and Wilson's suspicions that something is terribly wrong.

House and the team take on the case of Nick, a book editor who loses his inhibitions. The team realizes Nick has frontal lobe disinhibition, which causes him to speak his mind having no control over what he says and making him just like House. Meanwhile, House suspects Wilson and Taub are keeping something from him.

Morgan works in a nursing home with a pet cat who only sleeps next to people if they are about to die - and does so with alarmingly accuracy. When it seems the cat has predicted her own death, Morgan, convinced she is about to die, fakes a seizure in order to get to House to have him diagnose her before it’s too late.

A man awakens in New York after a bicycle accident unable to move or communicate in any way. House, himself injured in a motorcycle mishap, occupies the hospital bed next to Lee and quickly annoys the doctors treating them both by insisting that Lee has “locked-in” syndrome.

Charlotte, an older woman who has spent the last six months taking care of her dying husband Eddie, is rushed to Princeton Plainsboro after collapsing from respiratory failure. The couple becomes a double mystery for the team when Eddie begins to improve as Charlotte’s condition worsens. The previously unthinkable becomes real when it seems that Charlotte will die before Eddie, and the team will be forced to make a difficult decision.

Cameron postpones her vacation with Chase in order to ask House to accept the case of an environmental radical who collapsed at a protest with unexplainable symptoms. Although suspicious of her motives, House agrees. Since she pushed him to take the case so emphatically, House forces Cameron to take the lead and run many of the tests on the patient. Meanwhile, House is unsure of Wilson’s new healthy diet.

The team takes on the case of a deaf 14-year-old named Seth who collapsed after he started “hearing” explosions while competing in a wrestling match. When the team tries to test him for seizures, Seth loses vision in one eye, complicating House’s bunk theory of “Exploding Head Syndrome.” As his condition worsens, the team has an ethical disagreement about the patient and his mother’s adamant decision to forego cochlear implants to supplement his hearing. When the prospect of giving Seth the ability to hear for the first time in his life arises, House and the team are faced with a resounding decision. Meanwhile, House’s lack of sleep starts to play tricks on his mind, but he finds his insomnia may be a gift instead of a burden

House and the team take on the case of a ballerina whose lungs collapse in the middle of a performance. When the treatment causes her skin to fall off, the dancer faces not only the prospect of never dancing again but also of dying an agonizing death. The team must use their imaginations to carefully choreograph ways to test and treat her delicate body without killing her. Meanwhile, House continues to suffer from what he thinks is insomnia, and he is willing to go to desperate measures to cure it.

House and the team are intrigued by Scott, a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his actions. As the two sides of Scott’s brain struggle for dominance, his warring personalities make it increasingly difficult for the team to figure out what is causing the unique problem. The team is forced to use some unusual methods to get him to cooperate with their necessary testing. Meanwhile, when House refuses to make an appearance in the clinic, Cuddy takes an unconventional approach to force House to make up the time with a particular patient.

House engages in a battle of wits and wills against the attending physician in charge of his detox program. When he starts to lose, House resorts to blackmail to gain the upper hand.

House asks Alvie to help him uncover incriminating information about Dr. Nolan that would allow him to blackmail his way out of the treatment center and convinces Lydia to loan him her car to sneak out a delusional patient in an attempt by House to undermine Dr. Nolan's course of treatment. But when devastating events ensue, House is humbled into reluctantly accepting help.

House returns home to Princeton where he continues to focus on his recovery, but surprises Cuddy with the news that he's making a big change in his life. Meanwhile, the team is unable to diagnose a loud-mouthed video game creator who posts each new symptom on the internet and opts for treatments suggested by the online community rather than by the doctors, and Foreman angles for House's job, but the pressure to solve the case creates tension in his relationship with Thirteen.

When a controversial African politician falls ill, he is brought to Princeton Plainsboro for treatment. The team struggles with whether to help a merciless dictator being subpoenaed for crimes against humanity in his country. Meanwhile, Wilson tries to make peace with a feuding neighbor, but House’s prying exacerbates the problem.

A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son's medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present information on the Dibala case.

A dying patient insists that he has the same disease affecting his heart that killed his father and grandfather at the age of 40. Meanwhile, House discovers that he has a hearing problem while trying to duck student rounds.

After a wild night out, a teenage girl is brought to Princeton Plainsborough with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction. Meanwhile, Cuddy, Wilson and House spend a weekend away from the hospital to attend a medical conference, but things don’t go as planned when House’s private investigator, Lucas returns.

After House’s medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick, an adult film star admitted to Princeton Plainsborough for pulsating eye pain. Meanwhile, Cuddy is reminded that Princeton Plainsborough is not conducive to healthy personal relationships.

On the eve of Thanksgiving, House and the team take on the case of James Sidas, an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. For the ailing patient, intelligence is a miserable burden that has prompted depression and addiction, and this, coupled with a myriad of strange symptoms, nearly stumps the team. Meanwhile the doctors at Princeton Plainsboro wrestle with strained personal relationships.

When an old friend and former patient of Wilson’s exhibits paralysis in his right arm, Wilson puts himself on the case. House wagers Wilson that the patient’s symptoms are attributed to new cancer cells. Wilson accepts even though he is reluctant to believe the cancer has returned. With the help of the team, Wilson works to diagnose the patient more optimistic results, but when things take a turn for the worse, Wilson must address his inability to separate patient from friend. Meanwhile, Cuddy seeks advice in her search for real estate.

When drug dealer Mickey mysteriously collapses while negotiating a sale, his partner-in-crime, Eddie, accompanies him to Princeton Plainsboro for treatment. But with a major deal pending, Mickey is not forthcoming with the necessary personal information the team needs to treat him. As Mickey's condition worsens, the team resorts to old-fashioned detective work to solve the case. Meanwhile, House and Wilson compete for the affection of a new neighbor, and Chase, Thirteen and Taub attempt to play a practical joke on Foreman.

The team takes on the case of Valerie, an attractive female executive experiencing random episodes of excruciating pain. House agrees to take the case based on Valerie’s looks, and while treating her, the men on the team are charmed by Valerie’s beauty and personality, with Thirteen looking beyond the superficial to try to discover a link to her illness. Meanwhile, House uncharacteristically attempts to alleviate his conscience by reaching out to a former medical school colleague he wronged.

House and the team rush to treat an ailing college football star in time for the patient to compete in NFL tryouts. But when the patient experiences an onslaught of varied and unusual symptoms, the team has trouble reaching a consensus on how to effectively treat him in time. Meanwhile, Foreman’s brother Marcus makes a surprise visit to the hospital.

During a day in the life of Princeton Plainsboro's Dean of Medicine, Dr. Lisa Cuddy, the inner workings of the hospital are seen through her eyes. This day proves to be especially trying as Cuddy wrestles with myriad hospital issues and staff disputes that test her perseverance and skills as an administrator, all while juggling issues in her personal life.

House and the team take on the case of an avid blogger admitted with sudden bruising and bleeding. From her hospital bed, the patient blogs about her symptoms, doctors and prospective diagnoses to her dedicated band of followers and solicits their advice on a course of treatment. Such openness leads the team to contemplate the value of privacy, especially after House and Wilson uncover secrets from one another 's past. Meanwhile, Chase is coaxed into testing out the dating scene.

The team takes on the case of a high school senior who inexplicably blacks out during a class field trip. While in the hospital, the patient repeatedly hallucinates. After exhausting myriad ineffective treatments for her mysterious ailments, House attempts one last controversial approach to diagnosing her: monitoring her cognitive patterns and looking for clues. Meanwhile, Taub airs his dirty laundry at work, and Wilson attempts to furnish his condo.

This episode has five storylines: When the hospital is sent into lock-down mode due to a missing infant, all of the doctors must remain where they are, leaving Foreman and Taub in the file room, Wilson and Thirteen in the cafeteria playing truth or dare, House in a room with a patient, and Chase with his soon-to-be ex-wife, Cameron, as Cuddy tries to help police locate the infant. This episode is one of the show's rare instances when no medical mystery is presented, though House still deals with his "patient of the week".

House and the team take on the case of Sir William, a "knight" in a closed-off community of men and women living according to the ideals of the High Renaissance. As the team searches the medieval village for environmental factors contributing to Sir William's rapidly deteriorating health, Thirteen and Sir William debate the acts that define honor and loyalty, especially in regard to the "queen" of the community, one of Sir William's most frequent visitors. Meanwhile, Wilson starts over with an ex.

House and the team take on the case of a woman Julia, who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia's happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson's relationship with Sam.

The team takes on the case of an ailing groom-to-be who harbors undisclosed secrets from a previous relationship. As his fiancée tries to get answers to her many questions, a frustrated team winnows down the possibilities. Meanwhile, House spends extra-curricular time with his Princeton Plainsboro colleagues, performing a karaoke rendition of a Gladys Knight & The Pips classic with Foreman and Chase.

During a session with Dr. Nolan, House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.

Cuddy, House and members of the team join forces with a search-and-rescue team to provide much-needed medical attention at the scene of an emergency.

Po emocionálnom záveru minulej sezóny, v ktorom si House a Cuddy priznajú, že k sebe niečo cítia, začiatkom siedmej sezóny objavujú dôsledky týchto citov a snaží sa, aby vzťah fungoval. Medzitým, kvôli ochoreniu kolegami je Princeton Plainsboro bez neurochirurga a nemocnici tak hrozí, že príde o akreditáciu traumatického centra 1. stupňa. Keď sa tím snaží svojho kolegu uzdraviť, aby sa mohol vrátiť do práce, zisťuje, že za jeho chorobou sa skrýva niečo iné, než čakal, a tak sa obráti na House. Ale House je nedostihnuteľný a necháva tím osamote.

Keď Della (Alyson Stoner), zdanlivo zdravá a aktívna 14let dievča, náhle skolabuje počas skateboardové exhibície, House a jeho tím sa snaží určiť jej diagnózu a upokojiť tak jej rodičia, ktorí už sa tak musia vyrovnávať so smrteľným ochorením svojho syna. Potom čo jej telo odmietne darovanú pľúcach a čas na jej záchranu pomaly dochádza, je jej rodina ponechaná s malou nádejou na to, že sa nájde nový darca, a je tak postavená zdanlivo pred nemožné rozhodnutia, ktoré zasiahne osud oboch detí. Medzitým sa House na klinike snažia upokojiť postaršieho otca a jeho syna a spolu s Cuddy začínajú pociťovať následky, ktoré prináša fakt, že sa rozhodli previesť svoj vzťah na pracovisko.

Keď Alice (Amy Irving), autorka populárnej detskej knižnej série, začne mať nevysvetliteľne záchvat chvíľu predtým, než sa pokúsi si vziať život, stojí pred tímom v Princeton Plansboro výzva v podobe diagnostikovanie jej stavu ako toho záhadného zdravotného stavu tak aj toho nestabilného psychického. House, neschopný Alicu diagnostikovať, je ako fanúšik jej kníh obzvlášť motivovaný a je presvedčený, že sa kľúč k jej záhadnému zdravotnému stavu schováva medzi riadkami jej poslednej knihy. Medzitým House berie Cuddy na dvojité rande s Wilsonom a jeho priateľkou Sam (Cynthia Watros) a dochádza k zisteniu, ktoré dokazuje, že život napodobňuje umenie, keď sa pár naďalej snaží robiť kompromisy, aby ich vzťah fungoval.

Keď je do Princeton Plainsboro prijatá pacientka menom Margaret McPherson, potom čo nekontrolovane zvracala, House a tím počas posudzovania jej symptómov urobí neočakávaná zistení o jej totožnosti. Keď sa stav pacientky nezlepšuje, tím začne prechádzať jej anamnézu, aby o jej minulosti odhalil ešte viac. Medzitým House chladne privíta novú posilu, ktorú priviedol Chase, a návšteva houseové masérky prinúti House s Cuddy vytýčiť mantinely vo svojom vzťahu.

Potom čo novorodenec začne trpieť nevysvetliteľnými dýchacími ťažkosťami a zlyhajú mu pečeň, House a tím sa pozrie do chorobopisu jeho matky Abbey (Jennifer Grey), či by nenašli nejaká vodítka. Keď tím dôjde k zisteniu ohľadom zdravie jej novorodenca, je Abbey postavená cez ťažké rozhodnutia, ktoré nakoniec môže ovplyvniť ako jej tak aj zdravie jej dieťaťa. Medzitým, House na radu Cuddy vyzve Foremana a Taub, aby aj najali doktora - ženu, aby sa pridala k ich tímu. A keď potom Cuddy požiada House, aby strážil jej dieťa, dostanú House s Wilsonom poriadnu lekciu v rodičovstva.

Je obdobie volieb a uprostred tesného volebného súboja vedúcemu volebnej kampane úradujúceho senátora zlyhajú pečeň a je dočasne paralyzovaný. Cuddy tlačí na House, aby do tímu prijal ženu, a prinúti ho prijať vynikajúce študentku tretieho ročníka medicíny Marthu Masters (Amber Tamblyn) miesto neprítomnej Thirteen. House s tímom sú voči jej nedostatku skúseností a lekárskym stanoviskám skeptickí, ale sú prinútení dať tejto ich "všetko podľa pravidiel" kolegyňu šancu sa ukázať. Potom čo je kandidátom senátor urobí neočakávané vyhlásenie, House a tím sa na neho zameria, aby sa pokúsili u neho nájsť nejaká vodítka k stavu pacienta. Medzitým Foreman zistí, že Taub pozná Master už z minulosti, a House pri snahe zachrániť život svojho pacienta musí urobiť dôležité rozhodnutie, ktoré môže kompromitovať jeho vzťah s Cuddy.

Mladé dievča je prijatie do Princeton Plainsboro sa symptómy pripomínajúce kiahne, potom čo sa v jej ruke rozbila 200 rokov stará medicínska fľaštička z vraku lode neďaleko pobrežia. Keď však Dr Dave Broda (Dylan Baker) z Centra kontroly chorôb nariadi zaplombovanie nemocnice a odvolá Housův tím z prípadu, začína Masters (Amber Tamblyn) spochybňovať jeho motív a je presvedčená, že pacientka trpí inou chorobou. Otec dievčaťa čoskoro začne vykazovať rovnaké symptómy a House je prinútený urobiť nebezpečné rozhodnutie, ktoré postaví jeho vlastný život v nebezpečenstve. Medzitým Wilson sa Sam (Cynthia Watros) utešujú šesťročného pacienta (Devon Woods) na chemoterapiu, ktorý je prinúti, aby sa zamysleli nad svojím vzťahom.

Veda a viera je pozývaná, keď je hospitalizovaný pacient (Kuno Becker), ktorý bol hospitalizovaný potom, čo sa snažil znovu prehrať ukrižovania. Pacient, Ramon Silva, odmieta podstúpiť navrhnutú liečbu a tím sa tak dozvedá, že potom, čo rakovina jeho dcéry bola vyliečená, sľúbil Bohu, že sa obetuje. Ako Ramon zostáva čím ďalej tým menej času, tím sa snaží pochopiť jeho dôvody a akosi extrémne náboženské presvedčenie, ale nakoniec zistí, že viera nie je argument. Medzitým Taub vypočúva svoju ženu Rachel ohľadom jej vzťahu s členom skupiny podváděných a tím ide na svadbu kolegami, na ktoré sa vzťah Wilson a Sam dostane do nečakaných obrátok.

Keď muž (Matthew Lillard) dá napospas svoj vlastný život, aby zachránil život neznámej ženy, ktorá spadla do koľajiska metra, len zázrakom vyviazne z tejto dramatickej scény bez zranení, ale náhle skolabuje. Nemocnica aj mesto sú uchvátení mužovým nezjištním činom, ale keď tím pracuje na jeho diagnostike, zisťuje, že hrdinov zdanlivo životné čin sa nevymyká starým zvykom. Medzitým sa House snaží vyhnúť narodeninové večeru na počesť Cuddy s jej dogmatickú matkou Arlene (Candice Bergen). Taub sa dostane nečakanej pozornosti, keď sa objaví na billboardoch propagujúcich nemocnici po meste a zatiaľ čo so ženou znova podnieti svoj fyzický vzťah, Masters mu vďaka svojmu pohľadu zvonka pomôže pochopiť, že je čas podniknúť kroky na riešenie svojho rozpadajúceho sa manželstva.

Mladistvý vojenský cvičenec vo výcvikovom tábore pre mladistvých delikventov začne trpieť nezvyklými symptómy potom, čo vydržal intenzívny cvičebný tréning, a zo záhadného dôvodu je skoro hospitalizovaný aj jeho inštruktor (Sasha Roiz). Tím nie je schopný vypátrať príčinu ich choroby, a tak tím začne pátrať v rodinnej anamnéze instruktura. House a Masters (Amber Tamblyn) zistí, že medzi inštruktorom a cvičenca je mimoriadne puto. Medzitým, keď sa po troch rôznych stretnutiach na jednej zo sociálnych sietí objavia hanba fotografie Chase, je Chase odhodlaný zistiť, ktorá z dievčat sa ho snaží verejne zdiskreditovať. A keď House vidí, že je Cuddy vynervovaný z Ráchelina zápisu do prestížnej škôlky, tajne Rachel pripraví a ukáže sa, že má pre batoľa slabosť.

Cuddyina matka Arlene (Candice Bergen) je prijatie do Princeton Plansboro potom, čo si sťažuje na nezvyčajné symptómy. Arlene ale trvá na tom, aby bol House z prípadu odvolaný, čo House prinúti prísť s nekonvenčným - a ilegálnym - spôsobom liečby svojho pacienta. House nariadi tímu, aby ho nasledovali. Zistí, že Alrene pred svojimi dcérami Cuddy a Lucindou (Paula Marshall) skrýva tajomstvo. Medzitým bývalá manželka Taub Rachel spojí Taub so svojím bratom, ktorý Taub najme, pretože potrebuje nutne ďalšie príjem, čo si ale na ňom vyberie fyzickú i psychickú daň. Cuddy dôveruje House, že jej matka dostáva náležitú lekársku starostlivosť, čo vedie študentku lekárstvo "podľa predpisov" Masters k prehodnoteniu jej zodpovednosti postupovať podľa etického kódexu na plnenie príkazov svojho šéfa.

Keď servírka (Tina Holmes) s dokonalou pamäťou dočasne ochrnie, navštívi ju v nemocnici jej staršia sestra (Claire Rankin), ale táto návšteva spôsobí zvýšenie stresu a ešte ďalšie zdravotné komplikácie. Pacientčina dokonalá pamäť sa ukáže ako škodlivá, keď jej zadržiavaná zášť voči sestre skomplikuje obdržaní náležitej liečby, a Masters zistí, že zalepenie rozbitého vzťahu medzi sestrami je ďaleko komplikovanejšia, než diagnostikovanie pacienta. Medzitým sa Foreman ponúkne k pripravení Taub k lekárskej skúške, zatiaľ čo House je odhodlaný Wilsona s niekým zoznámiť a zistí, že Wilson už spoločníčku má.

House sa zúčastňuje v škole Dňa kariéry a pri tom poruší pár pravidiel, keď sa podelí o chúlostivé lekárskej historky. Ako čaká pred kanceláriou riaditeľa, stretne sa s dvoma žiakmi piateho ročníka (Austin Michael Coleman, Haley Pullos), ktorí posúdia House vzťahové problémy a pomôžu mu pochopiť, prečo jeho sebecké zdokumentovaných skrytých žartov bráni tomu, aby Cuddy ukázal, ako sa naozaj cíti.

Robotník (Adrian LaTourelle) je hospitalizovaný potom, čo u neho prepukla ťažká vyrážka, keď bol v práci vystavený chemikáliám. Ako ho tím lieči, zistí, že svoju ženu (Ashley Jones) nechal v presvedčení, že si stále drží svoju lukratívnu pozíciu ako realitný agent. Medzitým je Cuddy udelená cena a potrebuje, aby s ňou House šiel na charitatívnej akcii, ale jeho prítomnosť je ohrozená, keď pacienta boj o život ho prinúti premýšľať o svojej vlastnej praxi a šťastie. A Chase s Master si navzájom dajú lekciu vo vytváraní zmysluplných osobných a profesijných vzťahov.

Napätie dosiahne nových výšok, keď je Cuddy postavená pred správu nútiaca k zamysleniu, ktorá ju postrčí k prehodnoteniu svojich priorít. Kým House je rozptýlený obavami o Cuddyino zdravie, tím lieči mladistvého pacienta, ktorého zhoršujúce sa symptómy a podozrivé jazvy na tele naznačujú niečo viac než len fyzické ochorenia. Taub, ktorý vytuší nešťastný emocionálny a duševný stav mladíka, sa vydá hľadať vodítka v pacientovom osobnom živote a objaví znepokojivú domácu nahrávku, ktorá by mohla život jeho rovesníkov ohroziť. Medzitým Cuddy stále pevne dúfa, že House tu pre ňu bude, keď ho bude najviac potrebovať, a rad snov, vrátane muzikálovej scény s choreografiou od Mia Michaels, poskytnúť jej letmý pohľad do jej života a jej vzťahu s Housom.

Mladý šampión v zápase s býkmi je hospitalizovaný potom, čo bol kompenzovať jedným z nich. Po vykonaní nespočetných neprůkazných testov sa tím obráti na House, ktorý je mimo nemocnici a venuje sa pár záležitostiam mimo prípad. Späť v nemocnici sa stav toreadora zhoršuje, ale s mizícími symptómy a frekventovanějšími malými záchvaty sa tím rozhodne k riskantné operáciu s otvoreným srdcom. A Masters sa k Taubovu prekvapenie do mladého toreadora zamiluje.

Mladý bezdomovec, ktorý bol drogovo závislý, je nájdený v parku sa symptómy zhoršeného čuchu a hroznými jazvami a popáleninami na hrudníku. Cez neistú identifikáciu a pacientovým zhrošujícím so stavom tím číta jeho osobné záznamy a rodinnú anamnézu, aby pochopil jeho odlúčenie. A akonáhle tím pocíti k pacientovi sympatie, zistí o mužovej živote, ktorý zachránil, znepokojujúce tajomstvá. Medzitým sa Cuddy zverí Wilsonovi, že sa cíti vinná, že ukončila s Housom vzťah.

Thirteen bola posledné mesiace vo väzení, ale House skôr zaujíma, čo vykonala, že tam skončila. Keď je z väzenia prepúšťaná, je prekvapená, keď na ňu House čaká a netuší, že na najbližších pár dní má pre nich obaja pripravený program. Zatiaľ čo idú na každoročnú súťaž zemiakových zbraní a spojí svoje súťažné sily proti houseovom oveľa mladšiemu a príliš sebejistému rivalovi, House sa snaží z nej dostať informáciu o jej previnenie a je plne odhodlaný rozlúštiť všetko o jej záhadnom uväznenie a počas cesty odhalí tajomstvo a fakty o sebe navzájom. V nemocnici sa tím snaží liečiť učiteľa prírodovedy, ktorý trpí vážnymi respiračnými problémami. Keď idú do jeho bytu, aby skúsili nájsť nejaká vodítka k jeho ochorenia, ihneď zistí, že hromadia veci. Ale keď do jeho bytu zájdu druhýkrát, odhalí pod hromadami haraburdie niečo, čo je šokuje. A Taub sa snaží znova randiť, ale znovu spadne do svojich starých zvykov.

Masters čaká jej posledný deň ako študentky medicíny kariérny rázcestí, keď si musí vybrať medzi kariérou chirurga alebo výnimočnú príležitosť sa oficiálne stať členkou houseovom tímu. Medzitým sa tím snaží liečiť 16ledou dievča, ktoré nevysvetliteľne skolabovala pár dní pred nalodením na ambiciózny plavbu okolo sveta. Cez život meniace diagnózu trvá rodina pacientky na tom, aby sa na more vrátila včas a mohla začať svoju možná rekordný plavbu. Ale na prekvapenie tímu vrátane House urobí Masters odvážne rozhodnutie ohľadom pacientčiny liečby.

Víťaz lotérie Cyrus Harry (Donal Logue) je prevezený do princentonské nemocnice k House a jeho tímu potom, čo čiastočne ochrnul, keď hľadať svoju dávnu lásku. Cuddyina matka (Candice Bergen) vyhráža, že zažaluje nemocnicu za zanedbanie povinnej starostlivosti a do ohrozenia sa tak dostávajú lekárskej licencie House aj Cuddy. Chase a Foreman uzavrú stávku, ktorá každého z nich rôznym spôsobom preverí.

Keď sa House a Wilson vsadí ohľadom boxerského zápasu, a potom sa nemôžu dohodnúť o výsledku stávky, dá Wilson House presne jeden deň na zaplatenie alebo vyvrátenie svojho víťazstva. House začne tlačiť na boxera (Kevin Phillips) a chce po ňom informácie, ktoré by mu pomohli dokázať, že má pravdu. Nakoniec sa bude House snažiť vliať do jeho zkomírající zápasníckej kariéry nový život. Medzitým tím začne House podozrievať, že má ešte ďalší problém s drogami / práškom.

Priateľka a bývalá spoluväzenkyne Thirteen (Amy Landecker) sa neohlásená objaví v jej byte a nutne potrebuje lekársku starostlivosť. Keď ale Thirteen zistí, že jej priateľka sa zase vrátila k zneužívaniu drog, sľúbi jej, že ju nevezme do nemocnice, kde by ju mohla polícia nájsť a obráti sa so žiadosťou o pomoc na Chase. Medzitým sa House vyrovnanie s devastujúce správou a Taub sa zase zmieruje s jednou nečakanou.

Lekársky tím sleduje cez skrytú kameru umelecké vystúpenia ženy trpiace údajne neznámou chorobou. Žena si s nimi vlastne celý čas hrá a niektoré príznaky svojej choroby predstiera, aby lekára schválne zmiatla. Predovšetkým pre House je jej počínanie veľká výzva a postupne nadobúda presvedčenie, že žena má rakovinu.

House is serving out a lengthy prison sentence for his various misdeeds, including his trip outside the country in an attempt to escape responsibility. Entirely cut off from his old life, House determines his current problems are the result of his inability to deal with people. Feeling he will never be able to practice medicine again, he plans instead to go back to university to earn a doctorate in physics - a field that will all but assure his isolation from other human beings.

A surprising visitor makes House an offer he can't refuse by giving him the opportunity to help the Princeton Plainsboro team treat a unique patient in order to save the life of an organ recipient being treated by Wilson. Although House finds himself back on familiar ground, he quickly realizes that much has changed since he left, and he is forced to work on the case with smart yet timid resident Dr. Chi Park. After several inconclusive treatments and with time running out, House and Dr. Park are left with one last option to examine the patient's medical history that could compromise House's conditional agreement with the hospital. Meanwhile, House makes an effort to reconnect with Wilson despite a cold reception.

House and Park treat a patient, Benjamin, who collapsed after making a surprisingly large charity donation, and come to suspect that the altruistic behavior is a symptom of a deeper disorder. When the patient offers to donate an organ for another patient, the doctors must convince Dr. Adams to help them confirm whether Benjamin is in his right mind or not.

A CEO falls mysteriously ill just days before he signs a contract that would relocate his company's entire labor force to China. House attempts to make an underhanded business transaction with his wealthy patient, but when the patient's condition worsens, the team must work around the clock to save his life. Meanwhile, Park prepares for her hearing with the Princeton Plainsboro Disciplinary Committee chaired by Foreman, and Adams' outlook on her patient's business venture reveals her deeper feelings about loyalty.

A man well-respected in his community suddenly collapses, and in the process of diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life. But when the patient openly confesses his wrongdoings to his family and community, he compromises his chances of receiving the proper medical treatment. Meanwhile, House will stop at nothing to manipulate Taub into taking a DNA test to prove he is the father of his two six-month-old daughters.

A teenage boy attempting to follow in his late father’s footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.

The team learns that their 14-year-old patient is suffering from more than teen angst when her physical symptoms worsen. Despite Foreman’s firm opposition, House becomes obsessed with solving a peculiar case of a deceased four-year-old patient, which gets him into serious trouble. Meanwhile, Park tries to get Chase to admit the reason behind his recent obsession with grooming.

A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder.

House and his team treat an Alzheimer's patient who vomits blood and flies into violent rages. Meanwhile, when Wilson tells House about a patient who has never had sex with her husband of 10 years, claiming A-sexuality, House makes a wager with him that there has to be an underlying cause.

When a runaway teen requires hospitalization, Adams butts heads with House when she insists they contact Social Services. Meanwhile, Taub has trouble forming a personal connection with his baby daughters and Foreman's relationship with a married woman comes out.

House and his team are placed under review after a staff member gets hurt.

Chase's religious faith bubbles to the surface when he treats a young nun. In addition, he and House reach a fundamental disagreement about the patient that may finally end Chase's reputation as House's "yes man" but also bring's House's methods, reputation and objectivity are given more serious scrutiny.

House's green-card wife, Dominika, will return in order to prove to the proper authorities that she and House are actually married. This in turn will lead to a crash course in which both will learn a little something about love and marriage.

A successful, independent blind man is struck down with a mysterious illness, just prior to him asking for his girlfriend's hand in marriage. Meanwhile, House has a family member visit to inform him of a life change. "Love Is Blind" is the fourteenth episode of season eight of House and the 169th overall. The episode debuted in Canada on Global on February 27, 2012, and aired three weeks later in the United States on Fox on March 19, 2012. The unusual three-week delay was a byproduct of the 2012 Daytona 500 rain delay of 30 hours.

The team treats an Army veteran charged with treason after he leaked classified information. But the patient's life is put at risk when he refuses treatment unless he and his brother are given information about their late father, a war veteran, which raises questions about loyalty to one's family and country. Meanwhile, Adams suspects House may be sick, so she recruits Wilson and the other team members to plan an intervention and investigate his illness.

House and the team take on the case of a 22-year-old minor league hockey player who collapsed while coughing up blood after a fight on the ice. Meanwhile, House drops a bomb on Wilson, and Chase offers to help Park change her living arrangement.

House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker, since his current favorite, Emily, has decided to get married and leave the business. Desperate for Emily "companionship," House teams up with his "wife" Dominika to sabotage Emily's budding relationship.

House and the team take on the case of a young boy who has violent dreams of being choked, and then wakes up but still can't take in air. Meanwhile, Park is having intimate dreams involving co-workers, which causes the team to question whether or not there's significance to what each of them dreams. Dominika discovers House has been keeping a secret from her and Wilson drops a bombshell on him.

When House and Wilson disappear off the grid for several days, without explanation, the team is left to deal with a difficult case concerning a 6-year old with numerous problems and complications, including an overbearing mother who also happens to be her physician.

Over the years, during the course of performing autopsies at Princeton-Plainsboro, Dr. Peter Treiber has often identified mistakes made by physicians that caused the patient's death. These observations have left him questioning the skills of nearly all the doctors on staff... all, that is, except House. When he falls ill, he demands that only House make medical decisions concerning his care. Unfortunately, House and Wilson have taken off on an impromptu road trip without telling anyone, leaving the team to fend alone and lie to their patient to make him believe that House is the guy calling all the shots.

The team takes on the case of Derrick, a 19-year-old college student who had a mysterious nose bleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother’s voice in his head. Meanwhile, Foreman tries a different approach with House.

Facing a 6-month jail term, and the realization that he won't be there for Wilson at the end, House finds himself examining his entire life while contemplating a dismal future without his best friend.