House and the team take on the case of Sir William, a "knight" in a closed-off community of men and women living according to the ideals of the High Renaissance. As the team searches the medieval village for environmental factors contributing to Sir William's rapidly deteriorating health, Thirteen and Sir William debate the acts that define honor and loyalty, especially in regard to the "queen" of the community, one of Sir William's most frequent visitors. Meanwhile, Wilson starts over with an ex.

A children's novelist tries to kill herself, but is thwarted when she has a seizure. House, a fan of the books, puts her on psych hold but has to deal with a patient that is eager to die rather than be cured. Meanwhile, House worries that he'll lose Cuddy because they have nothing in common.

A patient is admitted after breaking out in a severe rash triggered by caustic chemical exposure at his blue-collar job. Meanwhile, Cuddy is honored with an award and needs House to be at the charity event for support, but his attendance is threatened when his patient’s battle to survive forces him to question his practice and his own happiness.

A homeless man with a history of drug abuse is admitted to Princeton Plainsboro with burns and scars on his chest. Meanwhile, Cuddy reveals her guilt to Wilson about breaking up with House.

A man well-respected in his community suddenly collapses, and in the process of diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life. But when the patient openly confesses his wrongdoings to his family and community, he compromises his chances of receiving the proper medical treatment. Meanwhile, House will stop at nothing to manipulate Taub into taking a DNA test to prove he is the father of his two six-month-old daughters.

A successful, independent blind man is struck down with a mysterious illness, just prior to him asking for his girlfriend's hand in marriage. Meanwhile, House has a family member visit to inform him of a life change. "Love Is Blind" is the fourteenth episode of season eight of House and the 169th overall. The episode debuted in Canada on Global on February 27, 2012, and aired three weeks later in the United States on Fox on March 19, 2012. The unusual three-week delay was a byproduct of the 2012 Daytona 500 rain delay of 30 hours.

When House and Wilson disappear off the grid for several days, without explanation, the team is left to deal with a difficult case concerning a 6-year old with numerous problems and complications, including an overbearing mother who also happens to be her physician.