Ο Coulson και η υπόλοιπη ομάδα (εκτός του Fitz) βρίσκονται απομωνομένοι σε ένα μυστηριώδες σκάφος κάπου στο διάστημα. Και αυτό είναι μόνο η αρχή του εφιάλτη που ακολουθεί...

Η Daisy αποφασίζει να σώσει την Simmons με οποιοδήποτε κόστος.

Ο Coulson και η ομάδα του ανακαλύπτουν τις πραγματικές προθέσεις των δεσμωτών τους. Και στο διάστημα η απόδραση δεν αποτελεί επιλογή.

Με την βοήθεια του Lance Hunter, τίποτε δεν θα σταματήσει τον Fitz να βρει τους φίλους του, καθώς ανακαλύπτουμε το ρόλο που καλείται να παίξει.

Με την ζωή της Daisy να κρέμεται σε μία κλωστή, ένας απροσδόκητος σύμμαχος θα προσπαθήσει να την σώσει.

Με την επανένωση της η ομάδας, γίνεται θήραμα ενός ανίκητου πολεμιστή των Kree.

Coulson and the team discover that the most unexpected person from S.H.I.E.L.D.’s past may hold the key to stopping Earth’s destruction.

Mack, Yo-Yo, and Flint fight to keep everyone alive by starting a revolution against the Kree.

The team has one final chance to return to the timeline, but their actions may have deadly consequences.

Coulson and the team set out to rewrite the course of humanity's fate; they're unaware that their efforts will dramatically change one S.H.I.E.L.D. agent's life.

In the milestone 100th episode, Coulson finally reveals the mysterious deal he made with Ghost Rider, which will impact everyone on the team.

The team goes in search of Gravitonium in order to save the world.

As Fitz and Simmons race to find a way to seal the Rift, they are faced with one of their greatest fears manifested.

Coulson uncovers General Hale's true agenda, and it could be the end of the world if S.H.I.E.L.D. doesn't help her.

Coulson is forced to team up with surprising allies to save the world, while the S.H.I.E.L.D. team attempts to track down and rescue him.

While an agent's life hangs in the balance, Fitz, Simmons, and Yo-Yo attempt to neutralize a weapon that could play a role in Earth’s destruction.

The team must find a way to stop Ruby before the prophesied chain reaction that can destroy the Earth is put into motion.

Coulson and the team find themselves under siege at the Lighthouse.

A newly determined Talbot takes Coulson to meet the enemy and attempts to avert Earth's destruction.

Daisy's future as the Destroyer of Worlds could take a critical change.

Coulson's life or death is the challenge the team finds themselves in, as the wrong decision will cause the Destruction of Earth.