When a new Inhuman is discovered, Coulson and the team have an encounter with another organization seeking powered people; Fitz goes to extreme measures to determine how to get Simmons back.

Fitz and the team enlist the aid of an Asgardian to unlock the secrets of the ancient Monolith that swallowed Simmons, and Agent May is at a crossroads in her personal and professional life.

Daisy, Mack and Coulson race to protect Lincoln as Rosalind’s team hunts down the Inhuman in their quest for powered people. Meanwhile, Hunter proves that there is no line that he will not cross to exact his revenge against Ward and HYDRA.

Coulson and the team search for the Inhuman who is killing other Inhumans. Meanwhile, May feels that Hunter's mission to take down Ward is getting too personal.

After her dramatic rescue from another planet, Simmons is still reeling from her ordeal and reveals how she had to fight for her life in a harsh new world.

The stakes get even higher as Hunter and May continue to go after Ward and HYDRA, and Daisy and Coulson begin to suspect that the ATCU may be keeping a big secret from S.H.I.E.L.D.

As Daisy and the team fight to protect Inhumans, S.H.I.E.L.D. discovers the shocking truth about one of their foes; Fitz helps Simmons recover information that could lead them back through the portal.

The S.H.I.E.L.D. team discovers dangerous truths about the ATCU, and Ward's plans to destroy S.H.I.E.L.D. take a surprising twist.

Ward's campaign for revenge brings the S.H.I.E.L.D. team to their knees, and Coulson proves he will do anything to settle the score.

A battle between HYDRA and S.H.I.E.L.D. will change Coulson's world; Fitz and Coulson take a huge risk.

In the aftermath of his trip to Maveth, Coulson is more determined than ever to get to Gideon Malick and put an end to HYDRA once and for all. Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D.?

Coulson and General Talbot are forced to team up and attend a worldwide symposium on Inhumans, where they suspect Malick has an inside man. As the S.H.I.E.L.D. team gets closer to the truth, an unexpected traitor is revealed.

Bobbi and Hunter become ensnared in an assassination plot after tracking Malick to Russia. As S.H.I.E.L.D. races to save the lives on the line, the team is changed forever.

When a radical group called The Watchdogs emerges with plans to eliminate the Inhumans, Agent Mack and his brother become caught in the crossfire. Meanwhile, Simmons discovers a powerful chemical compound that could alter the future for Inhumans.

When Daisy gets a horrifying glimpse of the future, S.H.I.E.L.D. races to prove that fate is not fixed.

S.H.I.E.L.D. hunts for information on their dangerous new enemy, and a shameful secret from Malick's past is exposed, threatening to destroy his HYDRA legacy.

Agent Daisy Johnson must call upon the Secret Warriors for an inaugural mission that will leave no member unscathed, and S.H.I.E.L.D. learns more about Hive's powers, forcing them to question everyone they trust.

The S.H.I.E.L.D. team is left reeling and decimated as Hive continues to sway Inhumans to his side. But there is a sliver of hope as Agents Fitz and Simmons follow a lead that may be able to stop the maniacal Inhuman once and for all.

Coulson and his team race to combat Hive's control over the Inhumans, as their enemy's deadly plan for the human race is revealed.

With only two episodes left before S.H.I.E.L.D. loses one of their own, Daisy's prophecy ticks closer towards a major loss, as the aftermath of the events of Captain America: Civil War force S.H.I.E.L.D. to register the Inhumans.

It's a showdown a season in the making as S.H.I.E.L.D. takes on Hive, and when his master plan is finally revealed, the team must spring into action. Who will live and who will die?