The enigmatic Dr. Helen Magnus recruits insightful forensic psychiatrist Will Zimmerman to join her in the quest to track, study and protect the strange and often terrifying creatures that secretly populate our world.

As Will attempts to help Alexi cope with his abnormality, Helen gets a visitor from her past.

Dr. Helen Magnus, her daughter Ashley, and new to the Sanctuary, Dr. Will Zimmerman release three women from a mysterious crypt in Scotland, bringing them back to the Sanctuary for refuge. Unbeknown to the team, and the women themselves, they have extraordinary powers. And their disappearance does not go undetected by a powerful cabal, resolute on reclaiming what it determines is theirs.

An investigation into a string of bizarre robberies leads Magnus and Will to a crime ring of thieves who seem to be able to slip between the cracks of the law… literally.

When a mating pair of cute, furry and seemingly harmless abnormals is brought in for scientific study, the Sanctuary team begins to exhibit some hidden animal attractions for one another.

While leading a covert meeting in Rome, Magnus encounters an old friend from her past who confides that the cabal has come to exact revenge on her for the events in "Fata Morgana."

A young artist with an uncanny ability to draw remarkably detailed pictures from memory may be the key to solving a case surrounding the suspicious death of his abusive father.

Magnus and Will investigate a distressing call for help deep below the Bermuda Triangle resulting in a deadly battle to save Magnus’s life.

Investigating the disappearance of an old college friend, Will finds himself caught in an underground fight club where the combatants are genetically engineered abnormals who fight to the death like modern day gladiators.

Magnus and the Sanctuary team attempt to capture a rare and deadly creature - all under the watchful eye of a local news crew.

Abnormals in remote regions are subjected to an airborne biological agent that compels them to launch a violent string of murders

The Five, led by Magnus, attempt to find the secret labyrinth in the decimated city of Bhalasaam. Once located, they must complete a series of cryptic tests that can only be achieved using each of their unique powers.