When the traveling Buffalo Bill Cody's Western Extravaganza settles in Toronto, murders happen. Inspector Murdoch must investigate the crimes while his boss becomes enamored with Annie Oakley.

An investigator arrives from Scotland Yard who is after the infamous Jack the Ripper. Meanwhile, Murdoch takes dancing lessons so that he can escort Dr. Ogden to a ball.

When the unveiling of a reconstructed dinosaur skeleton at a gala event reveals the dead body of a young man found in its jaws, Murdoch must enter the world of bone-hunters to find the culprit.

The young Harry Houdini becomes Murdoch's prime suspect when he investigates a daring robbery-homicide. Meanwhile, Dr. Ogden's sister comes to visit and soon becomes attracted to Murdoch.

As they investigate a young woman's death, Murdoch and Dr. Ogden find their relationship threatened when they turn out to be of opposite opinions in the matter of abortion.

Detective Murdoch fears that his relationship with Dr. Ogden has been permanently damaged, as he heads into investigating a seemingly perfect crime, the murder of a university professor. Meanwhile, Constable Crabtree continues his search for his biological mother.

Murdoch finds himself drawn to the widowed mother of a boy who has gone missing, but the case starts to take a strange turn involving spies, midgets and a robotic super weapon.

Dr. Ogden and Enid compete to nurse the injured Murdoch back to health, as in his delirium he begins to suspect his landlady of planning a murder. Meanwhile, Constable Crabtree investigates a case involving a disagreeable parrot.

The discovery of a decomposed body leads Murdoch into the fascinating world of telegraphy - the 1895 equivalent of the internet. When Murdoch calls on Enid to assist in the investigation, she finds herself in peril. Meanwhile, Inspector Brackenreid's erratic behavior has Dr. Ogden questioning the Gold Cure the Inspector is taking to help him stop drinking.

Murdoch's investigation into the death of a young Jewish man leads to Toronto's small Jewish getto - the Ward. There he finds a tale of forbidden romance and himself again being drawn to Dr. Ogden.

A savage murder, seemingly at the jaws of a wild beast, leads Murdoch into the mysterious worls of North American shamaism and lycanthropy. While searching for a reational explanation, Murdoch is forced to choose between Enid and Dr. Ogden.

While investigating a murder, Murdoch find himself teamed with a North West Mounted Policeman whose methods and mannerisms are strikingly similar to this own -- perhaps too similar? Murdoch hope to rekindle his relationship with Dr. Ogden -- but is it too late?