The CSIs investigate the murder of a dominatrix found near her secret sex dungeon.

As Halloween descends on Sin City, the CSIs investigate when a creepy mannequin prop inside a popular haunted house turns out to be a real dead body. Also, Catherine enlists the help of Folsom to search for her friend who disappeared.

The CSI team investigates after a group of teens discover a dead woman behind the wheel of an abandoned car in a Nevada ghost town.

When three masked assailants invade a home and murder an entire family, including a pregnant woman, the CSIs are called to the scene to investigate. Catherine leads the team through the emotional case, which intensifies her own longing to reconnect with her estranged daughter, Lindsey.

After all the guests attending an upscale fundraising soiree for the science department at a local university fall ill, the CSI team gears up to investigate. Also, Catherine enlists Grace’s roommate to help her find clues after Grace disappears.

Max leads her team to investigate the death of a prestigious Michelin-starred chef found hanging in his restaurant’s walk-in freezer.

A mysterious bigfoot-like footprint found near a crime scene puzzles the CSI team as they work to uncover who - or what - killed a father and son.

Catherine’s frustration intensifies when a lead suspect in Grace’s disappearance is found murdered. The team exhausts all their skills to figure out who killed the suspect, and if his death will lead them to Grace.

When the bodies of two Regency Romantic Festival attendees are discovered, the CSI team uncovers a shocking link between their murders and previous cases.

A social media influencer party ends with the brutal murder of a popular guest. Chris Park's side hustle makes him uniquely qualified to lead the CSI team in their investigation.

When a young, non-verbal boy is found hiding in a stranger’s garage, the CSI team searches for his missing mother. Also, Max receives a strange letter with symbols in silver ink that Folsom and Allie recognize from prior crime scenes.

Catherine’s day off with her granddaughter gets interrupted when a woman wakes up from a four-year coma and remembers details from the night her sister died.

CSI komanda izmeklē lietu par arheologa nāvi, kas atrasts netālu no senās civilizācijas atklājuma.

CSI izmeklē kāda ēšanas sacensību dalībnieka noslēpumaino nāvi, un Čavess sadarbojas ar Alliju, lai pierādītu noslēpumaino ar sudraba tinti rakstīto zīmīšu izcelsmi.

Noziegumu izmeklēšanas laboratorijā tiek atrasta ar sudraba tinti rakstīta zīmīte, kas apdraud Maksīnas Robijas dzīvību, un visa CSI komanda tiek sūtīta noskaidrot, kā šīs zīmītes ir saistītas ar citām slepkavībām.

Medicīnas izmeklētājas Sonjas dzīvība ir apdraudēta, jo viņa tiek pakļauta noslēpumainai indei, kad CSI komanda cenšas atrast pretlīdzekli un Sudraba tintes slepkavu, kas, šķiet, ir vērsies pret Noziedzības laboratoriju.

Kad Mīdas ezera dzelmē tiek atklāts pirms vairāk nekā 40 gadiem nogalinātas jaunietes līķis, Makss Robijs apsola viņas mātei Reikelai Viljamsai, ka CSI komanda beidzot atradīs slepkavu.

Kad nepamatoti apsūdzētais bijušais aizdomās turamais Džīns Farovs, klāts ar asinīm un ar nazi rokā, ienāk Noziedzības laboratorijā un meklē Alliju Rajanu, CSI komanda isāk zimeklēt viņa savdabīgo stāstu.

CSI komanda izmeklē lietu, kur zemesriekstu rūpnīcā ir atrasts miris izmeklēšanas reportieris. Savukārt visi noziedzības laboratorijas darbinieki ar bažām domā par to, kuru Makss paaugstinās par dienas maiņas vadītāju.

CSI komanda izmeklē slepkavību, kas notikusi Folsoma mājas tuvumā. Kad viņam tiek likts pārtraukt šo izmeklēšanu, viņš ar Treija palīdzību pats veic rakšanas darbus.