The Doctor and Sarah answer a distress call and find themselves on Zeta Minor, the last planet of the known universe, where a Morestran expedition has gone missing.

The Doctor realises that Zeta Minor lies on the boundary between the universes of matter and anti-matter and something on the planet won't let the Morestrans leave.

The Doctor makes a deal with the Anti-Matter Beast to return all the anti-matter to the planet but Sorenson is determined to continue his research.

The Doctor tries to convince Sorenson to sacrifice himself for the rest of the crew but Salamar's attempt to deal with the situation causes their problems to multiply.