在民国时期的上海滩中央巡捕房，拥有精湛专业实力的法医车素薇（董璇饰），与空降任职的绅士探长顾远（谷嘉诚饰）、自诩“沪上第一神探”的富二代副探长康一臣（苏小玎饰）、天真活泼的名门千金记者曹青萝（吕艳蓓饰），四人秉持着公正的信条，齐力破解一桩桩诡谲蹊跷的案件，还原真相，他们也在每一场关于正义的追逐中慢慢成长。

The play is set in the turbulent period of the Republic of China in Shanghai. In a turbulent era, the forensic doctor Che Suwei (played by Dong Xuan) and the gentleman detective Gu Yuan (played by Gu Jiacheng) are intertwined with various forces. "Deputy Inspector Kang Yichen (Su Xiaozheng), and the innocent and lively reporter Cao Qingluo (Lü Yanbei) worked together to crack out a number of weird and curious cases, and restore the truth.