"Dopo la fine della sua vita da impiegato, Kirio Reiji si ritrova in un mondo diverso come farmacista. Lì trascorre le sue giornate sviluppando prodotti farmaceutici e gestendo la sua farmacia. È aiutato in questa impresa dal lupo mannaro Noella e dalla ragazza fantasma Mina".

"Il detersivo per i piatti fa acqua da tutte le parti". Mina è felicissima della sua magica rimozione! Rage e i suoi amici portano il detersivo in regalo a Rena, la ragazza dell'insegna di una tavola calda del quartiere. Ma rimangono invischiati con la Red Cat Gang, le guardie di sicurezza della città, e ......!

Kirio Drugstore expands its product lineup and is enjoying its popularity when a tweedy gentleman shows up at the shop. He is the butler of Lady Flam, the wife of the town's lord, and has come to invite Reiji to her mansion. Reiji anxiously visits the mansion, where Lady Flam asks him to create a rejuvenating ointment for her dinner party five days from now. Reiji believes it's an impossible task, but reluctantly accepts the request and somehow manages to produce his "Beautiful Belle's Beautiful Skin Gel." However, the lady's daughter Elaine was eavesdropping on their conversation...

Reiji and Noela go to buy lunch at the nearby Rabbit Tavern. Noela loves the Rabbit Tavern's food and is excited to eat. Suddenly, they hear shouting coming from inside the restaurant. They cautiously look inside and discover the Rabbit Tavern's owner and poster girl Rena having an argument with the owner of a recently established rival restaurant. Not only has this restaurant stolen their customers, but it is apparently plotting to buy out the Rabbit Tavern as well. Seeing Rena's sadness, Reiji wishes he had some way to help the Rabbit Tavern.

The town is bustling with activity as it prepares for the Kalta Festival. The highlight of the event is the Hunting Festival in which skilled archers enter the woods to shoot monsters. For the past several years, an elf named Kururu has won every year. Meanwhile, Ririka the beautiful elf girl comes to Kirio Drugstore. She is Kururu's younger sister and wants to put her brother to shame. She believes that by winning the Hunting Festival, he will stop treating her like a child and acknowledge her as an adult and archer instead. She asks Reiji to make her a medicine that will make an archer as unskilled as herself win.

The physically powerful Noela accidentally breaks all of Kirio Drugstore's knives. She's scolded by Reiji, and together they go to the tool shop to do some shopping. However, for some reason it's dark and quiet inside the tool shop. Reiji experimentally calls out in a loud voice, and a blue-haired and bespectacled Paula finally lazily responds. Apparently she fell asleep on the floor because she's so busy. Reiji decides he'll try to do something to help Paula, who is overwhelmed with requests from the Red Cat Brigade and other townsfolk.

Charmed by how exceptionally tasty Reiji's potions are, Demon King Ejil decides to leave his castle to acquire even more. He expends a huge amount of mana traveling to Kirio Drugstore, but once he arrives, he's asked to pay for his potions. The displeased Ejil threatens Reiji, but Reiji doesn't give in. Just then, Noela appears, and when Ejil sees her...

The lord's butler Rayne returns to Kirio Drugstore. Apparently Lord Kasty wants to meet with Reiji. Reiji visits the mansion, where he is immediately accused by the lord. "Recently my daughter Elaine has been avoiding me! You're conducting psychological attacks so you can take Elaine from me!" Surprised by the accusation, Reiji asks for details and learns that the lord's daughter is simply avoiding her father because she's going through puberty...

Kirio Drugstore is closed today! Reiji and friends head out for a picnic and enjoy a relaxed day off at a lake in the woods. While Noela and Mina are playing in the water, Reiji and Ezil go fishing. Reiji uses his fish attracting "Big Catch Buddy" lure and gets a powerful bite! Together they manage to fish up their catch. However, instead of a fish, they've caught Vivi the lake spirit. Upon discovering how hungry she is, they invite her to eat sandwiches with them.

Vivi asks Reiji to make her a medicine that will make her stronger, but he responds that she shouldn't rely on medicines to fix all her problems. Instead, they ask Captain Annabelle of the Red Cat Brigade to help her train. Noela and Mina join their training session... but for some reason Reiji gets dragged into it as well, and he is forced to do jogging and strength training! Reiji immediately becomes exhausted and promises to make a medicine to promote muscle growth out of desperation.

Normally Paula visits Kirio Drugstore every day in hopes of scoring a free meal, but for the past week she hasn't been showing up. Reiji is concerned and goes to her tool shop to check on her, where oddly enough, she is studying. Reiji is surprised, so Paula explains that the exam to renew the license she needs to make her customers comfortable doing business with her is tomorrow, and she is currently studying for that. However, the results of her practice test were terrible, and Paula begs Reiji for help.

Reiji receives an invitation to a party from Elaine and her family to express their appreciation. Though he's unenthusiastic, when he sees Noela and Mina's excitement, he decides to attend. Since he has no clothes to wear to the party, he borrows Mina's father's suit, which reminds him of the depressing corporate wage slave life he lived before being reincarnated. He recalls how he met Noela when he first arrived in this world...