Iain's mistake with a patient has serious repercussions, putting many lives in danger.

Ciara comes back into Dylan's life, while the fallout from the crash affects the whole department.

After recent traumatic events, how will Alicia cope with returning to work earlier than expected?

David and Ciara fight over Dylan - who will he choose? Iain returns to work, trying to make up for Mia's death.

When Ciara comes into the hospital, Dylan faces a personal tragedy. Will he be able to stay on the wagon? Iain secures Base a place in rehab. Blake hears an anecdote about Jacob's mother Omo and becomes determined to find her.

Ruby and Iain are together for a shift, neither keen on the idea, and it gets worse when they find out they have been pranked by kids. A pregnant woman is involved in a car crash, and Duffy confides in an old flame.

Jacob is faced with his past. Will Iain's heroics stop him spiralling out of control?

Zsa Zsa returns to save Dylan, but can even she help him? Rash reels from his break-up with Gem.

It is judgement day for the ED, as the inspectors descend. Dylan has to face Ciara. Louise's management style frustrates the nursing team.

Base works for Ross in his meth lab to pay off his debts. He collects 16-year-old Harry to work with them, and watches on as Ross physically asserts his authority over the teenager. Duffy wakes up in a hotel room having slept with Bill. Full of guilt, she sends him away and gets ready to leave. On her way out, she hears a call for help and reluctantly treats Naima, who was found passed out in the hotel swimming pool by her fiance.

Determined to learn from medics in other departments, Louise is excited for a shift on the maternity ward. However, student nurse Jade stumbles into work late, and Louise is not impressed by her actions. Meanwhile, Charlie remains suspicious of Duffy, and Iain makes a call to the wellbeing team, finally seeking help about his mental-health struggles.

Dylan puts himself and Ciara in jeopardy when he takes a chance on love, while student nurse Marty (former EastEnders star Shaheen Jafargholi) arrives at the ED on his first day eager to please. Louise witnesses an elderly man being robbed by a gang of youths on bicycles, but soon learns not to judge a book by its cover. Elsewhere, Iain gets the runaround when asking for help, and Duffy catches Charlie answering her phone.

In the aftermath of the crash, Ciara is desperate to get away, but Dylan is determined to treat those who have been injured - despite receiving a head wound himself. On his return to the hospital, he reflects on his hopes for a future with Ciara in spite of everything that has happened, while at home, Ciara considers her own needs.

After a hard day, Iain seeks comfort in the wrong place. Duffy makes a shocking diagnosis

Bill is admitted to the emergency department suffering from chest pains. Charlie agrees to help him find out if his daughter is still drinking, but ends up discovering his affair with Duffy. A teenager is brought in after having been apprehended by the police, and while Ethan wants to discharge her as soon as possible, Alicia suspects her case may be more complicated. Marty tries to arrange a date with Joshua - but they may end up having some company.

Dylan faces a traumatic Christmas in Resus. Noel is delighted to have met his Christmas fundraising goal, but can't quite decide on a charity to give the money to.

Iain gets beaten up, and Marty chooses his career over friendship with Jade.

Alicia learns to trust her own medical opinion, and after self-diagnosing herself with dementia, Duffy visits a doctor to get checked. Robyn bans Marty from looking after Charlotte after she finds out he gave her a temporary tattoo, Marty and Jade fight over which of them needs to move out, and Iain and Ruby agree to forget about the kiss.

Alicia finds out that she has been offered a place on a coveted paediatric fellowship in Manchester, forcing her to make a decision on her future. Elsewhere, Marty's lies begin to catch up with him, while Elle is disappointed when she has to hand back to reins as clinical lead to a returning Connie.

Iain heads to Base's flat, but when he does not answer the door he becomes concerned and climbs through a window, only to find Base has taken an overdose. Louise goes out of her way for Ernest when he comes to the ED for a once-over, while Gem and Ruby look for somewhere new to live when Alicia's house goes on the market.

Jan learns the truth about her son and forgives Iain, while Ethan begins to move on from Alicia. Louise stands up for Jade and vows to protect her team in the future, Duffy panics when she forgets that she bought Charlie a birthday present, and Iain signs up for his first counselling session.

Ernest arrives for his surgery, only to find it has been cancelled as there are not enough beds. Louise sets to work freeing up a bed for him, but it is soon taken by another more critical patient. Connie is attacked by an unknown assailant on a flight of stairs, while Rash asks Gem to help him decide between paediatrics and cardiology.

Iain reaches out to someone from his past, but he does not get the response he was hoping for. Connie cannot remember the attacker, and is terrified that they could still be out there. Meanwhile, Marty and Jade learn to work together and decide to call a truce, and Louise takes a stand and hands her resignation to Charlie.

Marty plays counsellor for a couple who having problems with their relationship. After a busy and fulfilling day - treating patients including a girl involved in a hit and run accident, and two women who are attacked in a nightclub - Iain feels that his work with Ruby is done. Elsewhere, Dylan sees maggots cleaning a wound and gets an idea, and Ruby moves in with Jade and Marty.

A cyber-attack rocks Holby hospital at the worst possible time. Meanwhile, Ruby learns to trust her instincts as Iain’s life hangs in the balance.

The aftermath of Iain's attempted suicide ripples its way through the emergency department. Gemma struggles to come to terms with what has happened, and makes it her mission to piece together why Ian attempted suicide. Meanwhile, wracked with guilt, Ruby goes out of her way for a patient, and Connie tells Elle off for addressing the team about Iain's progress.

Duffy finally lets Charlie in on her big secret and tells him about her Vascular dementia diagnosis. Charlie decides that it may be best to pull her from the night shifts, when symptoms are most likely to appear. Meanwhile, new registrar Archie Hudson is thrown into the deep end on her first day after leaving her hospital induction early, and Connie reluctantly praises Elle's success.

Archie butts heads with charming paediatric locum registrar Will Noble when they meet in the car park. Will reconnects with old university friend Ethan and ingratiates himself with the staff by treating them to coffees and getting to know them. Archie is not fooled by his charm offensive and keeps a close eye on Will. Elsewhere, Jade learns she's passed her exams by the skin of her teeth, and Gem thanks Jan and Ruby for their help.

Charlie snaps under the pressure of keeping Duffy's ill health a secret, and Rash puts aside his dreams of travelling the world to stick by Gem. Connie is shocked when a paramedic is attacked by an unknown assailant. Meanwhile, Dani arranges to meet with Ruby, and secretly activates a tracker on Ruby's phone.

Connie comes face to face with her attacker, and Will goes above and beyond what is expected of him, but his actions only make things worse. Meanwhile, Ruby starts to feel uncomfortable when Dani keeps turning up out of the blue, Jade's nursing registration comes through, and Jan and Ruby discuss Iain's return.

With Gem’s help, Rash makes the choice to follow his dream of travelling. Will risks Connie’s wrath to help a patient, Charlie realises that he has underestimated Duffy, and Jade is excited to finally be a registered nurse.

Working as a 999 call handler helps Iain learn to open up, though he feels frustrated not to be out in the field.

Iain goes above and beyond on his first day back as a paramedic after his suicide attempt, and Duffy starts to doubt whether she should have been so open about her diagnosis. Meanwhile, Connie offers Will another interview, and Elle is left feeling hurt when Connie doesn't react to her choice to take a new job.

Will faces the biggest medical dilemma of his career when Toby returns to the ED. Ruby continues to keep Dani a secret, allowing her to get even closer. Charlie and Duffy renew their vows, and Marty returns to the ED from secondment to find Jade miffed that he didn’t keep in touch

Elle learns the truth about her new job and confronts Connie to find out if she gave her a glowing reference to get her out of the emergency department on purpose. Meanwhile, Jacob makes a shocking discovery about his mother leaving psychiatric care, and Ruby continues to hide the truth from Dani and her team.

Iain steps up and offers his support to Jan. Trouble shooter Ciaran arrives in the Emergency Department. With just three months to turn things around, he is determined to shake things up, much to Connie's dismay. Meanwhile, Jacob decides to confront Jet in an effort to fight for his mother's wellbeing.

Ruby plucks up the courage to confess about Dani, Jade finds someone who believes in her and starts to believe in herself, Ciaran is tested by the team and discovers he’s got a battle on his hands, and Archie and Will bond over making fun of Ciaran’s productivity charts.

Connie’s worst fears are realised when she comes back from her conference to find Ciaran has taken over her ED and her office. Everything important to her is slipping away. Meanwhile, Jacob uncovers the truth about his mother and vows to protect her.

Duffy makes the tough decision to hang up her uniform. Jacob discovers a truth from his past. Connie is furious with Ciaran when she finds out that Duffy has stepped down.

Jacob says a final goodbye to Omo, and a desperate Archie turns to Ciaran for help.

Iain learns to put patients first without compromising his mental health. Jade is gutted when she discovers Marty has won the bursary, until she hears about all the obstacles he has overcome to get to where he is. Gem considers joining Rash on his travels, but decides to stay for Iain's sake.

Connie takes the opportunity to prove herself, but it ends in disaster. Duffy proves her worth in the ED but gets caught in the middle of Connie's mistake.

Reliving the events of the previous day and unable to escape her own guilt, Connie schemes to save herself by planting a seed of doubt in Duffy's mind. Meanwhile, New porter Rosa makes quite the first impression in the emergency department. As she goes beyond the requirements of her role and gets involved with the patients, David thinks she is overstepping the mark.

When David sees that Charlie is struggling to cope, he intervenes and tries to remind Charlie that he is not alone, with his work 'family' there to help him every step of the way. Meanwhile, Marty's mother is rushed into the emergency department, and he and Jade have to keep up the pretence of being boyfriend and girlfriend in front of his family. Elsewhere, Connie continues to cover her tracks as Ciaran and Archie decide to keep an eye on her, hoping to catch her out.

Feature-length episode of the hospital drama with the staff of Holby's accident and emergency department as they deal with more sick and injured patients. The walls start to close in on Connie when the hospital board notices the high rate of benzodiazepine prescriptions in the emergency department, and she is forced to choose between her addiction and her career. Meanwhile, Iain takes a stand as he defends the paramedics in the emergency department, and Duffy learns that she does not need to be a nurse to be able to help others.