The Jane Pauley Show is an American syndicated talk show packaged by NBC Universal, hosted by veteran journalist Jane Pauley. The show premiered on August 30, 2004.

Pauley and other people involved with the show, before its premiere, were not aware of how she would adapt to the medium. Pauley has shown that she can handle serious interviews, but it was not immediately evident if she could hold her own in a medium which is heavily laden with impersonality.

The show's ratings were not impressive, and the show was canceled, with the final episode airing in May 2005.

The show was broadcast from the studio formerly occupied by The Today Show.