February 2020. Doc is determined to keep his team together that is falling apart: Giulia will move to Genoa, Lorenzo will perhaps leave medicine, Gabriel is leaving for Ethiopia and even Elisa no longer seems interested in the department.

While Andrea seems intent on leaving everything, refusing to deal with the difficult case of the nurse Giacomo, a new internist, Damiano Cesconi, and a new infectious disease specialist, Cecilia Tedeschi, arrives in the hospital, but above all a new primary, who seems ready to dismantle the department from the inside.

In this special episode, while the investigation conducted by Caruso comes to life and the secrets of the pandemic begin to emerge, Andrea faces a difficult choice: to get back the primary he must take tests, but if he fails, he will never be able to be a doctor again.

Dealing with the case of a young tennis phenomenon, Andrea is forced to wonder if it is worth stopping being "Doc" to pursue the primary.

Engaged in following two cases at the same time to prove that he is up to the primary, Doc is in direct competition with the new primary and takes several risks.

While a small war breaks out between Doc and the surgeon Valenti because of Carolina, Doc must face the case of a boy with very present parents and is forced to question himself as a father.

While Caruso's tests have the increasingly clear intent to put Doc in difficulty, Cecilia also begins to discover the secret of the team.

To treat an imprisoned mother, accused of trying to kill her daughter, Doc must fight against the prejudices of the entire hospital, just as he himself is being targeted by the investigation.

While our doctors are forced to take care of a patient, the rift between Doc and Carolina widens more and more, and Andrea must deal with himself.

Agnese is surprised to find Manuel's mother hospitalized, the child she has in foster care with Davide, and with whom things do not seem to go too well. Agnese will have to question everything she thinks she knows, just when Andrea seems to want to be closer to her than ever.

It's the day of the primary simulation for Doc: Andrea for a day returns to wear the gown, but a sudden computer blackout of the hospital's systems forces him to a series of risky choices.

While the doctors are busy solving the delicate case of a deafblind boy, Cecilia makes Doc an unexpected offer, triggering the jealousy of Agnese and Giulia.

Giulia is forced into a showdown with her cumbersome mother when her partner is hospitalized in the grip of an inexplicable syndrome. Just when Doc seems to be returning to primary, Cecilia discovers something compromising about him.

When he is one step away from regaining the primary, Doc is forced to a painful confession in front of the whole department.

Locked in the ward in a forced quarantine, doctors are engaged in a fight against time to stop a multidrug-resistant bacterium that has infected them all.