Season 1 of Cárcel de mujeres premiered on August 17, 2007.

Camila Padro, a well-renowed journalist is accused of murdering her husband is given eight years in prison. Upon arriving there, she is confronted with the violence and aggressiveness of the inmates.

Season 2 of Cárcel de mujeres premiered on November 12, 2008.

Nadia Meyer was raised in a prostitution house in Valparaíso and is the daughter of an American sailor who she never met. She was raped by her stepfather when she was a teen, when she grew up she kills him and imprisoned for that. Years later she becomes the leader in the women's prison.