After getting into a car accident in a rural Kentucky town, Kimble lands in jail by the redneck sheriff who hates outsiders. But Kimble manages to escape with his cellmate Davey ""Fatso"" Lambert. Hiding out at the Lambert ranch, Kimble sees that Davey's father and brother, Frank, treat the slow-witted Davey badly for blaming him for a barn fire years earlier. Kimble tries to prove Davey's innocence as Gerard flies out to Kentucky after learning of Kimble arrest and forms a posse to track him down.

Working as a stock clerk in a department store, Kimble witnesses his boss, Martin Rowland, accidentally kill a business associate in the parking lot after hours. When Kimble learns that a local vagrant found near the crime scene is the prime suspect, Kimble anonymously phones Rowland to get him to confess to the murder. But Rowland and his wife, Ginny, thinking that the caller is blackmailing them, hires the store detective, Angstrom, to find the person ""blackmailing"" Rowland.

Kimble is working as the caretaker at a spacious ranch in Connecticut which is owned by newspaper heiress Ann Guthrie who lives with her husband Harlan and her sister Ruth. Ann and Ruth's late father founded the Westborne Clarion, the newspaper that Harlan currently runs. Although Ann is the sole benefactor of her father's estate, she believes Ruth is entitled to part of the fortune. But Ann is unaware that the greedy Ruth is having an affair with Harlan and they plot to murder Ann and claim everything. When Kimble suspects Ruth and Harlan's plan and informs Ann, the skeptic heiress refuses to believe Kimble. Knowing that Kimble knows, the crafty couple plot to frame him for Ann's murder.