Wereldwijd stort de samenleving in door aggressieve schimmel die mensen omvormt tot meedogenloze monsters. In die wereld moeten Joel en Ellie trachten te overleven.

In 2003, an Indonesian scientist makes a devastating discovery. In 2023, now outside of the quarantine zone, Joel and Tess clash over Ellie's fate as they navigate a long-abandoned Boston overrun with Infected.

After a harrowing trek across a desolate United States, Joel and Ellie find themselves navigating a dangerous Kansas City on foot. Later, rebel leader Kathleen instigates a manhunt – one that pits her violent civilian militia against the world's best hope.

On the streets of a newly free Kansas City, Henry fights to protect his brother Sam from rebel soldiers who will stop at nothing to appease their ruthless leader. As her manhunt continues, Kathleen doubles down on her quest for revenge, while Ellie forms a meaningful friendship.

After months of traveling, Joel and Ellie receive a grave warning about what lies ahead. Later, Ellie learns more about Joel's past – while Joel tries his best to forget.

As Joel fights to survive, Ellie’s struggle to save him stirs memories of her life in a FEDRA orphanage. Weeks before meeting Joel, Ellie recalls joining her best friend Riley for a night to remember… one that will change the course of both of their lives – and the fate of the world – forever.

After crossing paths with a vengeful group of survivors, Ellie's fighting spirit draws unwanted attention from its leader. Still battling for his life, a weakened Joel faces off with a hunting party out for blood.

After being pursued by Infected, a pregnant Anna places her trust in a lifelong friend. Years later, Ellie is forced to grapple with the emotional toll of her journey, while Joel faces a devastating decision of his own.