Yes, it is possible.
First you need to know what the Gender IDs are.
They will be used as a filter or parameter in the search.
https://developers.themoviedb.org/3/genres/get-movie-list
https://api.themoviedb.org/3/genre/movie/list?api_key=[MY_KEY]&language=en-US

Second, use the Filter or Genre parameter in your Request.
https://developers.themoviedb.org/3/discover/movie-discover
For example, using Action (28) and Adventure (12) and Crime (80).
https://api.themoviedb.org/3/discover/movie?api_key=[MY_KEY]&language=en-US&page=1&primary_release_year=2019&with_genres=28,12,80

Also note that a number of filters support being comma (,) or pipe (|) separated.
Comma's are treated like an AND and query while pipe's are an OR.