A samurai lord has bartered away his newborn son's organs to forty-eight demons in exchange for dominance on the battlefield. Yet, the abandoned infant survives thanks to a medicine man who equips him with primitive prosthetics—lethal ones with which the wronged son will use to hunt down the multitude of demons to reclaim his body one piece at a time, before confronting his father. On his journeys the young hero encounters an orphan who claims to be the greatest thief in Japan.

Tokyo in the 1970s. Evil spirits are threatening the human world and the only ones who can stop them are a group known as the Spirit Patrol. Sent from the underworld the team consists of the hot-headed Enma, the stuck-up Yukiko, the half-water sprite Kapael and Chapeau-jii — the old man spirit in the form of a hat, who guides the group. This may not bode well... though.

Hyakkimaru is a young man who lacks 48 body parts because they were taken from him by demons before birth, as payment by his father, Kagemitsu Daigo, to obtain his wish to take over the country. When the baby boy was born he was missing 48 parts of his body, and thus was abandoned—thrown into a river. Hyakkimaru has grown up and now has obtained fake body parts so he can eliminate the 48 demons that were made from his body, and to retrieve his missing parts. Along for the adventure is the boy thief, Dororo, with whom he becomes friends.

Komachi is a little ghost who died during the Meiji Era and has hung around earth as a wandering spirit girl for over a hundred years. Komachi appears in the room of a young girl named Anko and the two get wrapped up in all sorts of adventures involving other ghosts and demons.

Dororon Enma-kun, also known as Satanikus!, is a Japanese horror-comedy anime and manga series created by Go Nagai. It's one of Nagai's most famous works in Japan, although not very well known in the rest of the world. In 2006, it would get a sequel/remake in Demon Prince Enma, which drops the comedy and becomes a full-fledged suspense-horror series. After the OVA was released, another manga version was released called Satanikus ENMA Kerberos by Eiji Toriyama. A remake entitled Dororon Enma-kun MeeraMera began airing in Japan in April 2011.