Morioh, 1999—a normally quiet and peaceful town has recently become a hotbed of strange activity. Jōtarō Kūjō, now a marine biologist, heads to the mysterious town to meet Jōsuke Higashikata. While the two may seem like strangers at first, Jōsuke is actually the illegitimate child of Jōtarō's grandfather, Joseph Joestar. When they meet, Jōtarō realizes that he may have more in common with Jōsuke than just a blood relation. Along with the mild-mannered Kōichi Hirose and the boisterous Okuyasu Nijimura, the group dedicates themselves to investigating recent disappearances and other suspicious occurrences within Morioh. Aided by the power of Stands, the four men will encounter danger at every street corner, as it is up to them to unravel the town's secrets, before another occurs.

An adaptation of the original five volume arc of the popular JoJo's Bizarre Adventure manga, covering the Phantom Blood chapters. Jonathan Joestar is an aristocratic boy whose life is suddenly turned upside down by a mysterious new boy who arrives, Dio Brando. Dio has a connection to his father, and over time, a rivalry forms as Dio becomes obsessed with a mysterious, ancient, and mystical stone mask that Jonathan's father keeps.

Kujo Jotaro is a normal, popular Japanese high-schooler, until he thinks that he is possessed by a spirit, and locks himself in prison. After seeing his grandfather, Joseph Joestar, and fighting Joseph's friend Muhammad Abdul, Jotaro learns that the "Spirit" is actually Star Platinum, his Stand, or fighting energy given a semi-solid form. Later, his mother gains a Stand, and becomes sick. Jotaro learns that it is because the vampire Dio Brando has been revived 100 years after his defeat to Jonathan Joestar, Jotaro's great-great-grandfather. Jotaro decides to join Joseph and Abdul in a trip to Egypt to defeat Dio once and for all.