Rangeela (Arshad Warsi) y Guddu (Amit Sadh) son del norte de la India, ambos son primos. Tocan orquesta. Pero quieren ganar dinero de cualquier manera. Un día, la información proporcionada a los mafiosos locales sobre las familias más ricas de la ciudad, les ha proporcionado una forma fácil y segura de subsistir sin ensuciarse las manos en el trato. Entonces secuestran a Baby (Aditi Rao Hydari). Se suponía que iban a obtener 10 millones de rupias como cantidad de secuestro. Después de secuestrarla, tienen que enfrentar muchos problemas. Pero de repente Billu Pahalwan (Ronit Roy) entra en acción. Es político y cambia el juego de Guddu Rangeela. Entonces la historia toma un giro interesante.

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When Guddu and Salina end up in a car accident, Salina loses her sight. Guddu soon finds out that he has a brain tumour, and decides to donate his eyes to Salina.

Guddu Ki Gun is the tale of Govardhan aka Guddu (Kunal Kemmu), a Bihari settled in Kolkata. He is a door-to-door washing powder salesman, whose sales pitch is "Ek washing powder ke saath Guddu free". While sharing a room with his close friend Ladoo (Sumeet Vyas), Guddu leads an amorous lifestyle in Kolkata. His travails begins when he ditches one of his girlfriends, Bholi (Aparna Sharma). Furious for forsaking his granddaughter, Bholi's grandfather casts a black magic spell on him. The only way Guddu can get rid of the curse is to find true love and by staying faithful to her.

Guddu is a teenager and Gangadhar is a middle aged gangster. They have nothing in common but due to some magic realism their lives got entangled in such a way that it created pandemonium after pandemonium.