While studying at the Department of Tourism and Hotel Management of Bogazici University, he started drawing comics for the Turkish humor magazine Leman. In August 1995 he did his first stand-up comedy show in "Leman Culture Center" performing with no serious career intentions as a comedian. However, after the positive response of the audience, he continued his show to attract larger crowds in Besiktas Cultural Center where he has appeared in over a thousand stand-up comedy shows since, becoming so popular that tickets have sold for 250TL (approx. US$140).

His movie career started in 1998 with a co-starring role in the comedy Everything's Gonna Be Great (1998), directed by Ömer Vargi, and continued with a role in Vizontele (2001), directed by Yilmaz Erdogan and Ömer Faruk Sorak. He achieved his greatest success by starring in and writing big-budget science-fiction parody G.O.R.A. (2004), also directed by Ömer Faruk Sorak, which despite spending several years in production because of financial and other technical problems became a box-office hit and described by Rekin Teksoy as a strong sign that showed that popular cinema was successful in appealing to wide audiences. He maintained this success with a starring role in the comedy feature movie Magic Carpet Ride (2005) AKA 'Magic Carpet Ride', also directed by Yilmaz Erdogan, for which he won Best Supporting Actor at the 11th Sadri Alisik Awards, and his directorial debut with The Magician (2006), co-directed by Ali Taner Baltaci, for which he won Best Actor at the 34th Brussels International Independent Film Festival and 12th Sadri Alisik Awards. He has since repeated his box office success with a sequel to G.O.R.A. (2004) called A.R.O.G (2008), also co-directed by Ali Taner Baltaci, and comedy Western parody called Yahsi Bati - The Ottoman Cowboys (2009), directed by Ömer Faruk Sorak. That same year, he co-starred, alongside veteran actor Sener Sen, in the police drama Hunting Season (2010), written and directed by Yavuz Turgul, and made a special appearance in drama Zefir (2010), written and directed by Belma Bas. After two years he also acted in Ferzan Özpetek's A Magnificent Haunting (2012). After he filmed his last stand-up comedy show CM101MMXI Fundamentals (2013) directed by Murat Dündar, he announced that for the next few years he will stop his stand-up comedy shows to have a rest.

Along his professional career, he has won numerous awards and appeared in more than 4000 stand-up comedy shows, took part in 10 movies and contributed as a dubbing performer in 4 movies.

​Cem Yılmaz (d. 23 Nisan 1973, İstanbul) komedyen, oyuncu, müzisyen, karikatürist, senarist ve yönetmen. Doğumundan sonra çocukluğu 11 yaşına kadar Kocamustafapaşa - Samatya'da geçti. Kocamustafapaşa'da ki Mehmet Akif Ersoy İlkokulu'nda 4. sınıfta okurken aile Bahçelievler'e taşındı. Ortaokulu Bahçelievler Kazım Karabekir Ortaokulu'nda bitirdi. Lise öğrenimi Etiler Anadolu Otelcilik ve Turizm Meslek Lisesi'nde görmüştür. Boğaziçi Üniversitesi Turizm ve Otel Yönetimi bölümünde okurken, bir mizah dergisi olan Leman'da karikatür çizmeye başladı. İlk gösterisini Mayıs, 1995'de Leman Kültür Merkezi'nde yaptı. Gösterilerine Beşiktaş Kültür Merkezi'nde devam etti. Bu gösteriler sırasında binlerce kişinin ilgisini çekmeyi başardı. Sinema kariyeri 1998'de vizyona giren "Her Şey Çok Güzel Olacak" Altan ile başlayarak, Vizontele Fikri, Organize İşler Müslüm Duralmaz ve Ramon filmlerindeki rollerle devam etti. Bunun yanında Hokkabaz adlı filmi vizyona girdi. Yüksek bütçeli bilim kurgu/komedi filmi G.O.R.A. 2004'de, A.R.O.G 2008'de ve Yahşi Batı 2010'da gösterime girdi. Filmin senaryosunu yazan Cem Yılmaz, filmde 4 ayrı karakteri canlandırmıştır. Çeşitli reklam filmlerinde de oynamıştır.Panasonic marka cep telefonlarının reklam filmleri ile reklam filmlerinde oynamaya başlamıştır.Daha sonra askere gitmeden önce, içinde askere gitmeyi de konu eden Mavi Jeans reklamlarında oynadı.Bundan sonra sırasıyla, Telsim reklamlarında, Doritos, Opet ve Türk Telekom gibi birçok reklam filminde yer aldı.